Interferon-Based Treatment of Hepatitis C Virus Infection Reduces All-Cause Mortality in Patients With End-Stage Renal Disease : An 8-Year Nationwide Cohort Study in Taiwan

doi:10.1097/MD.0000000000002113

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Title:	Interferon-Based Treatment of Hepatitis C Virus Infection Reduces All-Cause Mortality in Patients With End-Stage Renal Disease : An 8-Year Nationwide Cohort Study in Taiwan
Authors:	Hsu, Yueh-Han Hung, Peir-Haur Muo, Chih-Hsin Tsai, Wen-Chen Hsu, Chih-Cheng Kao, Chia-Hung
Contributors:	生活應用與保健系
Keywords:	population-basedcohort hemodialysis-patients antiviraltreatment kidney-disease increasedrisk hcvinfection association dialysis outcomes metaanalysis
Date:	2015-11
Issue Date:	2016-04-19 19:04:31 (UTC+8)
Publisher:	Lippincott Williams & Wilkins
Abstract:	The long-term survival of end-stage renal disease (ESRD) patients with hepatitis C virus (HCV) infection who received interferon treatment has not been extensively evaluated.The HCV cohort was the ESRD patients with de novo HCV infection from 2004 to 2011; they were classified into treated and untreated groups according to interferon therapy records. Patients aged <20 years and those with a history of hepatitis B, kidney transplantation, or cancer were excluded. The control cohort included ESRD patients without HCV infection matched 4:1 to the HCV cohort by age, sex, and year of ESRD registration. We followed up all study participants until kidney transplantation, death, or the end of 2011, whichever came first. We assessed risk of all-cause mortality by using the multivariate Cox proportional hazard model with time-dependent covariate.In the HCV cohort, 134 patients (6.01%) received interferon treatment. Compared with the uninfected control cohort, the treated group had a lower risk of death (hazard ratio 0.47, 95% confidence interval [CI] 0.22-0.99). The untreated group had a 2.62-fold higher risk (95% CI 1.24-5.55) of death compared with the treated group. For the HCV cohort without cirrhosis or hepatoma, the risk of death in the treated group was further markedly reduced (hazard ratio 0.17, 95% CI 0.04-0.68) compared with that in the control cohort.For ESRD patients with HCV infection, receiving interferon treatment is associated with a survival advantage. Such an advantage is more prominent in HCV patients without cirrhosis or hepatoma.
Relation:	Medicine, v.94 n.47, Article ID e2113
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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