Correlation between antibiotic consumption and carbapenem-resistant Acinetobacter baumannii causing health care-associated infections at a hospital from 2005 to 2010

doi:10.1016/j.jmii.2014.02.004

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標題:	Correlation between antibiotic consumption and carbapenem-resistant Acinetobacter baumannii causing health care-associated infections at a hospital from 2005 to 2010
作者:	Tan, Che-Kim Tang, Hung-Jen Lai, Chih-Cheng Chen, Yun-Ying Chang, Ping-Chin Liu, Wei-Lun
貢獻者:	保健營養系
關鍵字:	Acinetobacter baumannii Antibiotic resistance Antibiotic use Health care-associated infection
日期:	2015-10
上傳時間:	2016-04-19 19:04:21 (UTC+8)
出版者:	Elsevier Taiwan
摘要:	Background/Purpose: This study investigated the correlation between antibiotic consumption and the incidence of health care-associated infections (HCAIs) caused by imipenem-resistant Acinetobacter baumannii (IRAB) at a hospital in Taiwan from 2005 to 2010. Methods: Data on annual consumption (defined daily dose per 1000 patient-days) of extended-spectrum cephalosporins, beta-lactam-beta-lactamase inhibitor combinations, carbapenems, aminoglycosides, and fluoroquinolones from 2005 to 2010 were analyzed. Yearly aggregated data on the number of nonduplicate clinical IRAB isolates causing HCAI were collected. The incidence rates of HCAI caused by IRAB were defined as the number of patients infected with IRAB per 1000 inpatient-days. Results: The trend of total consumption (defined daily dose per 1000 patient-days) of extended-spectrum cephalosporins, carbapenems, and fluoroquinolones was significantly increased, but the use of aminoglycosides decreased during 2005 to 2010. During the same period, the incidence of HCAI caused by IRAB gradually increased. The consumptions of carbapenems and fluoroquinolones were positively correlated with the incidence of HCAI caused by IRAB. There was no significant association between the use of extended-spectrum cephalosporins, beta-lactam-beta-lactamase inhibitor combinations, and aminoglycosides and the incidence of HCAI caused by IRAB. Conclusion: The increasing use of carbapenems and fluoroquinolones was associated with the increasing incidence of HCAI caused by IRAB.
關聯:	Journal of Microbiology Immunology And Infection, v.48 n.5, pp.540-544
显示于类别:	[保健營養系(所) ] 期刊論文

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