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    標題: Alpha-carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice
    作者: Liu, Yi-Zhen
    Yang, Chih-Min
    Chen, Jen-Yin
    Liao, Junn-Wang
    Hu, Miao-Lin
    貢獻者: 老人服務事業管理系
    關鍵字: α-Carotene
    β-Carotene
    Lewis lung carcinoma
    Metastasis
    Taxol
    日期: 2015-06
    上傳時間: 2016-04-19 19:03:02 (UTC+8)
    出版者: Elsevier Science Inc
    摘要: This study aimed to investigate the anti-metastatic activity of alpha-carotene (AC) in Lewis lung carcinoma (LLC) and in combination with taxol in LLC-xenografted C57BL/6 mice. Cell culture studies reveal that AC significantly inhibited invasion, migration and activities of matrix metalloproteinase (MMP)-2, -9 and urokinase plasminogen activator but increased protein expression of tissue inhibitor of MMP (TIMP)-1, -2 and plasminogen activator inhibitor (PAI)-1. These effects of AC are similar to those of beta-carotene at the same concentration (2.5 mu M). AC (2.5 mu M) also significantly inhibited integrin beta 1-mediated phosphorylation of focal adhesion kinase (FAK) which then decreased the phosphorylation of MAPK family. Findings from the animal model reveal that AC treatment (5 mg/kg) alone significantly decreased lung metastasis without affecting primary tumor growth, whereas taxol treatment (6 mg/kg) alone exhibited significant inhibition on both actions, as compared to tumor control group. AC treatment alone significantly decreased protein expression of integrin beta 1 but increased protein expression of TIMP-1 and PAI-1 without affecting protein expression of TIMP-2 and phosphorylation of FAK in lung tissues, whereas taxol treatment alone significantly increased protein expression of TIMP-1, PAI-1 and TIMP-2 but decreased protein expression of integrin beta 1 and phosphorylation of FAK. The combined treatment produced stronger actions on lung metastasis and lung tissues protein expression of TIMP-1, TIMP-2 and PAI-1. Overall, we demonstrate that AC effectively inhibits LLC metastasis and suppresses lung metastasis in combination with taxol in LLC-bearing mice, suggesting that AC could be used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs. (C) 2015 Elsevier Inc. All rights reserved.
    關聯: Journal of Nutritional Biochemistry, v.26 n.6, pp.607-615
    顯示於類別:[老人服務事業管理系] 期刊論文

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