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請使用永久網址來引用或連結此文件:
https://ir.cnu.edu.tw/handle/310902800/29639
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| 標題: | Risk of Sudden Sensorineural Hearing Loss in Patients with Psoriasis: A Retrospective Cohort Study |
| 作者: | Yen, Yung-Chang
Lin, Yung-Song
Weng, Shih-Feng
Lai, Feng-Jie |
| 貢獻者: | 醫務管理系 |
| 關鍵字: | Systemic-lupus-erythematosus
Population-basedcohort
Diabetes-mellitus
Cardiovascular-disease
Arterial stiffness
Inner-ear
Migraine
Arthritis
Comorbidities
Inflammation |
| 日期: | 2015-06 |
| 上傳時間: | 2016-04-19 19:02:56 (UTC+8) |
| 出版者: | Adis Int Ltd |
| 摘要: | Significance Psoriasis, a common immune-mediated disease, affects approximately 2 % of the population worldwide. Sudden sensorineural hearing loss (SSNHL) might be a manifestation of systemic vascular involvement in autoimmune disease. However, to the best of our knowledge, there is no systematic English-language examination of the risk of SSNHL in patients with psoriasis.Objectives We tested the hypothesis that psoriasis is a risk factor for developing SSNHL.Methods Using Taiwan's National Health Insurance Research Database, we conducted a retrospective cohort study to compare patients diagnosed with psoriasis from January 1, 2001 through December 31, 2006 (n = 28,817) with gender-, age-, and comorbidities-matched controls (n = 28,817). We followed each patient until the end of 2011 and evaluated the incidence of SSNHL for at least 6 years after the initial psoriasis diagnosis.Results The incidence of SSNHL was 1.51 times higher in the psoriasis cohort than in the control cohort (7.12 vs 4.73 per 10,000 person-years). Using Cox proportional hazard regressions, the adjusted hazard ratio (AHR) was 1.51 (95 % confidence interval [CI] 1.18-1.93). Comorbid hypertension was an independent risk factor for SSNHL (AHR 1.49; 95 % CI 1.05-2.13). However, the incidence rate ratios (IRRs) for each comorbidity subgroup in the psoriasis and control cohorts were not significantly different.Conclusions and Relevance Psoriasis was significantly associated with a higher risk of developing SSNHL. We suggest that physicians advise patients with psoriasis to seek medical attention if they have hearing impairments, because they may also have a higher risk of developing SSNHL. |
| 關聯: | American Journal of Clinical Dermatology, v.16 n.3, pp.213-220 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
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