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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/29587


    標題: The potential use of diisononyl phthalate metabolites hair as biomarkers to assess long-term exposure demonstrated by a rat model
    作者: Hsu, Jen-Yi
    Ho, Hsin-Hui
    Liao, Pao-Chi
    貢獻者: 嘉南藥理大學分析檢測中心
    關鍵字: Diisononyl phthalate
    Metabolites
    Long-term exposure
    Hair
    Biomarker
    日期: 2015-01
    上傳時間: 2016-04-19 19:01:11 (UTC+8)
    出版者: Pergamon-Elsevier Science Ltd
    摘要: Diisononyl phthalate (DINP) is a widely used industrial plasticizer. People come into contact with this chemical by using plastic products made with it. Human health can be adversely affected by long-term DINP exposure. However, because the body rapidly excretes DINP metabolites, the use of single-point urine analysis to assess long-term exposure may produce inconsistent results in epidemiologic studies. Hair analysis has a useful place in biomonitoring, particularly in estimating long-term or historical exposure for some chemicals. Several studies have reported using hair analysis to assess the concentrations of heavy metals, drugs and organic pollutants in humans. As a biomarker, DINP metabolites were measured in rat hair in animal experiments to evaluated long-term exposure to DINP. In addition, we evaluated the correlation between the levels of DINP metabolites in hair and in urine. The levels of DINP metabolites in rat hair were significantly higher in the exposure group, relative to the control group (p < 0.05). DINP metabolites had a positive correlation with increasing administered dose. Significant positive correlations for MINP, MOINP and MHINP were found between hair and urine (r = 0.86, r = 0.79 and r = 0.74, respectively, p <0.05). Several metabolites in urine showed earlier saturation than in hair. In this report, we detected eight metabolites in hair and demonstrate that hair analysis has potential applications in the assessment of long-term exposure to DINP. (c) 2014 Elsevier Ltd. All rights reserved.
    Appears in Collections:[分析檢測中心] 期刊論文

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