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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/29240


    標題: 紫雲膏藥膠布新劑型開發研究
    Study on developing of a new patch form of Tzyy-Yun-Gau
    作者: 陳儀馷
    貢獻者: 藥學系
    黃秀琴
    關鍵字: 紫雲膏水性藥膠布
    Tzyy-Yun-Gau water-based patch
    日期: 2014
    上傳時間: 2015-10-26 20:28:48 (UTC+8)
    摘要: 中文摘要紫雲膏源自於明朝《外科正宗》之潤肌膏。紫雲膏自古即為我國常用之外用軟膏,主要用於燙傷、曬傷、刀傷、凍傷或潰瘍等,有助於傷口修復及癒合。紫雲膏為紫紅色之油膏,塗抹於皮膚時容易沾染衣物,造成不便。因此若能以藥膠布劑型使用,將改善其缺點,讓使用上更方便。紫雲膏傳統製法為以麻油加熱萃取當歸及紫草藥材,因麻油加熱之溫度極高,當歸及紫草藥材之有效成份易被破壞。因此,以麻油加熱萃取是否適當,須探討。為了尋找最適之萃取方法。本研究以麻油、50%及95%乙醇及正己烷等四種不同溶劑分別以超音波振盪法及加熱迴流法萃取方法來萃取當歸和紫草藥材,先以TLC進行當歸及紫草藥材指標成份定性分析,再以HPLC分析當歸及紫草指標成份ferulic acid及shikonin。選擇指標成份含量最高之溶劑及方法為最適萃取條件。結果顯示,當歸藥材以50%乙醇,紫草藥材以95%乙醇皆以超音波震盪法萃取最適。以此萃取條件大量萃取當歸及紫草藥材各1.25公斤,製成每片10×14公分,重量12克之紫雲膏水性藥膠布,共810片。並建立當歸、紫草藥材及紫雲膏水性藥膠布TLC指標成份定性分析及高效能液相層析儀 (HPLC) 定量分析方法確效。結果顯示紫雲膏水性藥膠布每片之ferulic acid及shikonin 之含量分別為347.6及11.7μg。本研究結果提供紫雲膏水性藥膠布製程及品質管制上之參考。
    AbstractTyzz-Yun-Gau originated from the Run-Ji-Gau of Wai-Ke-Zneng-Zong, Ming Dynasty. Tyzz-Yun-Gau was commonly being used as external using ointment since ancient of China, it mainly used on burns, sunburn, cuts, frostbite and ulcers, etc. It helps wound to recover and heal. Tyzz-Yun-Gau is a violet-red, applied to the skin easily stained in dress, causing inconvenience. If we can with patch, will improve this defect and more convenient to use.Tyzz-Yun-Gau was made traditionally with sesame oil, heat extraction Angelicae sinensis radix (ASR), and Arnebiae radix (AR). Because sesame oil can generate high temperature thus the effective ingredient of ASR and AR can be easily destroyed. Therefore, heat extraction by sesame oil is appropriate or not, should be studied. In order to fine the best extracted condition, we use four different solvents, including sesame oil, 50% ethanol, 95% ethanol, n-hexane, respectively, by ultrasound extraction and refluxation extraction to ASR and AR. TLC were the first to ferulic acid and shikonin marker compounds component qualitative analysis of ASR and AR,then were analyzed by HPLC, respectively. We choose the highest marker compounds solvents and methods for best extraction conditions. The results showed that the best extracted condition was by ultrasound with 50% ethanol extraction ASR and 95% ethanol extraction AR. The extraction condition also was used on extracting 1.25Kg of ASR and AR to make the Tyzz-Yun-Gau water-based patch, 10×14 cm, 12g per piece patch, and total had 810 pieces patches. In this study, we were established TLC to qualitative marker compounds and HPLC analysis validation to quantitative index compounds, ferulic acid and shikonin of Tyzz-Yun-Gau water-based patch. Ferulic acid and shikonin content were 347.6 and 11.7μg per patch, respectively. The results of this study will provide a reference of manufacture process and quality control of Tyzz-Yun-Gau water-based patch.
    關聯: 網際網路公開:2019-09-03,學年度:102,62頁
    Appears in Collections:[藥學系(所)] 博碩士論文

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