含溫度感應性載體及微脂粒之奈米纖維製備及其藥物釋放之研究

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 博碩士論文 > Item 310902800/28957

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標題:	含溫度感應性載體及微脂粒之奈米纖維製備及其藥物釋放之研究 The manufacture of nanofibers that contain thermo-sensitive carriers and liposome and their application in drug release
作者:	林盈湄
貢獻者:	化粧品應用與管理系李佳芬
關鍵字:	藥物控制釋放氮-異丙基丙烯醯胺微脂粒 Drug control release N-Isoproplyacrylamide Liposome
日期:	2015
上傳時間:	2015-10-21 17:06:16 (UTC+8)
摘要:	本研究主要是將模擬藥物分別包覆於溫度感應性高分子載體及微脂粒中，並將此包覆模擬藥物的溫度感應性高分子載體，並以特殊的紡絲技術製備出奈米纖維，並進行藥物控制釋放及各項性質之研究。實驗研究主要分為兩個部份進行探討，第一部分為製備微脂粒(Liposome)之研究，在此研究中，使用動物性飽和脂質為原料，並以不同實驗條件進行微脂粒的製備，於研究結果中顯示添加膽固醇所製備的微脂粒其粒徑較為穩定，因此可藉由添加膽固醇來提高微脂粒之穩定性；此外並將所製備的微脂粒於特定溫度的環境中放置30天，並於放置期間內觀察微脂粒的粒徑變化，評估微脂粒儲存在不同溫度下之安定性。第二部份的研究為製備具溫度感應性的空心乳膠顆粒，並將模擬藥物包覆於空心乳膠顆粒中，利用穿透式電子顯微鏡(TEM)及散射式電子顯微鏡(SEM)觀察交聯劑含量對於空心乳膠顆粒外觀形態及結構之影響，此外，將上述的微脂粒以及溫感型高分子載體製備成奈米纖維，並探討奈米纖維之藥物釋放狀態。 In this study, the model drug was encapsulated inside the thermos-sensitive polymer carriers and liposome respectively, and was manufactured to form the nanofiber by a special spinning method. The behavior of the drug released from the nanofiber was investigated in this study. This study included two parts, the first part was to manufacture the liposome. In this study, the first part was to manufacture the liposome by using the lipid was materials. Besides, the effect of various variables on the properties of liposome were investigated. The liposomes were stored in the condition of difference temperature for 30 days to study the stability of particles size. The results showed that the addition of cholesterol might enhance the stability of liposome. The second part was to manufacture the thermos-sensitive polymer particles with hollow structure. The model drug was encapsulated inside the hollow zone of the polymer particles. The TEM and dynamic laser light scattering were used to study the morphology and particle size of the hollow polymer particles that loaded with model drug respectively. Moreover, the liposome and hollow polymer particles were manufacture to form the nanofiber, and the properties of the fiber were studied.
關聯:	網際網路公開：2020-08-31，學年度：103，290頁
显示于类别:	[化妝品應用與管理系(所)] 博碩士論文

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