PURPOSE: To compare the cataract surgery related complications between patients with and without tamsulosin treatment. DESIGN: A nationwide retrospective case-control study. METHODS: Patients who had undergone cataract surgery were identified using the International Classification of Disease, Ninth Revision, Clinical Modification from a nationally representative dataset of 1 million people selected from the Taiwan National Health Insurance Research Database in 2000. Patients preoperatively treated with alpha(1)-blockers before cataract surgery were the treated group, and age-, sex-, and year of surgery matched patients not preoperatively treated with alpha(1)-blockers were the control group. Patients treated with tamsulosin underwent subgroup analysis. A conditional logistic regression model was used to estimate surgery-related complications and interesting variables. The main outcome measures are cataract surgery related complications. RESULTS: A total of 4474 treated patients and 4474 controls were analyzed. The percentage of cataract surgery related complications was 8.61% in the treated group and 8% in the control group (not significantly different). However, wound dehiscence was 3.81 times higher (95% confidence interval: 1.24-11.67, P = .0194) in the tamsulosin-treated group. CONCLUSIONS: Patients treated with tamsulosin have a higher risk of wound dehiscence after cataract surgery. Carefully taking a history of tamsulosin use before cataract surgery is advised so that some strategies can be used to prevent complications and additional costs. (C) 2014 by Elsevier Inc. All rights reserved.
American Journal of Ophthalmology, v.158 n.6, pp.1215-1220