Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28692
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    標題: Self-focusing Au@SiO2 nanorods with rhodamine 6G as highly sensitive SERS substrate for carcinoembryonic antigen detection
    作者: Quyen, Tran Thi Bich
    Chang, Chun-Chao
    Su, Wei-Nien
    Uen, Yih-Huei
    Pan, Chun-Jern
    Liu, Jyong-Yue
    Rick, John
    Lin, Kai-Yuan
    Hwang, Bing-Joe
    貢獻者: 生物科技系
    關鍵字: ENHANCED RAMAN-SCATTERING
    SEMICONDUCTOR QUANTUM DOTS
    GOLD NANORODS
    SILICA NANOPARTICLES
    LIVING CELLS
    LUNG-CANCER
    LIVE CELLS
    SURFACE
    NANOCRYSTALS
    CEA
    日期: 2014
    上傳時間: 2015-05-06 21:25:21 (UTC+8)
    出版者: Royal Soc Chemistry
    摘要: A highly sensitive self-focusing surface-enhanced Raman scattering (SERS) methodology has been developed using Au@SiO2 core-shell nanorods for carcinoembryonic antigen (CEA) detection. The SERS enhancement factor was evaluated for anisotropic Au@SiO2 nanorods with silica shells of various thicknesses, upon which Rhodamine 6G (R6G) dye was applied as a reporter molecule for the quantitative determination of CEA. The highest R6G signal was attained with a silica layer of 1-2 nm thickness. The self-focusing character originates from the antibody-antigen interaction, which facilitates the SERS probes assembly and significantly increases the detection sensitivity of the CEA. Our results show that the SERS technique is able to detect CEA within a wide concentration range. With an extremely low limit of detection (LOD) of 0.86 fg mL(-1), the Au@SiO2 nanoprobes potentially enable the early diagnosis of cancer. Our work offers a low-cost route to the fabrication of sensing devices able to be used for monitoring cancer progression in natural matrices, such as blood.
    關聯: Journal of Materials Chemistry B, v.2 n.6, pp.629-636
    显示于类别:[生物科技系(所)] 期刊論文

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