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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28691


    標題: Self-assembly behaviors of thermal- and pH- sensitive magnetic nanocarriers for stimuli-triggered release
    作者: Kuo, Chih-Yu
    Liu, Ting-Yu
    Hardiansyah, Andri
    Lee, Chia-Fen
    Wang, Man-Sheng
    Chiu, Wen-Yen
    貢獻者: 化粧品應用與管理系
    關鍵字: Tri-block copolymer
    Poly(acrylic acid-b-[N-isopropylacrylamide]-b- acrylic acid)
    pH- and thermo- responsive polymer
    Magnetic nanocarriers
    Stimuli-triggered drug release
    日期: 2014-09
    上傳時間: 2015-05-06 21:25:19 (UTC+8)
    出版者: Springer
    摘要: In the present work, we prepare thermo- and pH-sensitive polymer-based nanoparticles incorporating with magnetic iron oxide as the remote-controlled, stimuli-response nanocarriers. Well-defined, dual functional tri-block copolymer poly[(acrylic acid)-block-(N-isopropylacrylamide)-block-(acrylic acid)], was synthesized via reversible addition-fragmentation chain-transfer (RAFT) polymerization with S, S'-bis(alpha,alpha'-dimethyl-alpha ''-acetic acid) trithiocarbonate (CMP) as a chain transfer agent (CTA). With the aid of using 3-aminopropyltriethoxysilane, the surface-modified iron oxides, Fe3O4-NH2, was then attached on the surface of self-assembled tri-block copolymer micelles via 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride/N-hydroxysuccinamide (EDC/NHS) crosslinking method in order to furnish not only the magnetic resources for remote control but also the structure maintenance for spherical morphology of our nanocarriers. The nanocarrier was characterized by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), and ultraviolet-visible (UV/Vis) spectral analysis. Rhodamine 6G (R6G), as the modeling drugs, was encapsulated into the magnetic nanocarriers by a simple swelling method for fluorescence-labeling and controlled release monitoring. Biocompatibility of the nanocarriers was studied via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, which revealed that neither the pristine nanocarrier nor the R6G-loaded nanocarriers were cytotoxic to the normal fibroblast cells (L-929 cells). The in vitro stimuli-triggered release measurement showed that the intelligent nanocarriers were highly sensitive to the change of pH value and temperature rising by the high-frequency magnetic field (HFMF) treatment, which provided the significant potential to apply this technology to biomedical therapy by stimuli-responsive controlled release.
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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