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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28673


    標題: Repetitive hyperbaric oxygen therapy provides better effects on brain inflammation and oxidative damage in rats with focal cerebral ischemia
    作者: Chen, Li-Fan
    Tian, Yu-Feng
    Lin, Cheng-Hsien
    Huang, Lian-Yu
    Niu, Ko-Chi
    Lin, Mao-Tsun
    貢獻者: 保健營養系
    關鍵字: cerebral ischemia
    hyperbaric oxygen
    oxidative stress
    日期: 2014-09
    上傳時間: 2015-05-06 21:24:41 (UTC+8)
    出版者: Elsevier Taiwan
    摘要: Background/Purpose: Repetitive hyperbaric oxygen (HBO2) therapy may cause excessive generation of reactive oxygen species. This study assessed whether repetitive or 2-4-day trials of HBO2 therapy (2 treatments daily for 2-4 consecutive days) provides better effects in reducing brain inflammation and oxidative stress caused by middle cerebral artery occlusion (MCAO) in rats than did a 1-day trial of HBO2 therapy (2 treatments for 1 day). Methods: Rats were randomly divided into four groups: sham; MCAO without HBO2 treatment; MCAO treated with 1-day trial of HBO2; and MCAO treated with 2-4-day trials of HBO2. One treatment of HBO2 (100% O-2 at 253 kPa) lasted for 1 hour in a hyperbaric chamber. Results: Therapy with the 2-4-day trials of HBO2 significantly and dose-dependently attenuated the MCAO-induced cerebral infarction and neurological deficits more than the 1-day trial of HBO2 therapy. The beneficial effects of repetitive HBO2 therapy were associated with: (1) reduced inflammatory status in ischemic brain tissues (evidenced by decreased levels of tumor necrosis factor-alpha, interleukin-1 beta, and myeloperoxidase activity); (2) decreased oxidative damage in ischemic brain tissues (evidenced by decreased levels of reactive oxygen and nitrogen species, lipid peroxidation, and enzymatic pro-oxidants, but increased levels of enzymatic antioxidant defenses); and (3) increased production of an anti-inflammatory cytokine, interleukin-10. Conclusion: The results provide the apparently contradictory finding that heightened oxygen tension reduced oxidative stress (and inflammation), which was reflected by increased antioxidant and decreased oxidant contents under focal cerebral ischemia. Copyright (C) 2014, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.
    Appears in Collections:[保健營養系(所) ] 期刊論文

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