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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28663

    標題: Rational Domain Swaps Reveal Insights about Chain Length Control by Ketosynthase Domains in Fungal Nonreducing Polyketide Synthases
    作者: Liu, Ting
    Sanchez, James F.
    Chiang, Yi-Ming
    Oakley, Berl R.
    Wang, Clay C. C.
    貢獻者: 化妝品應用與管理系
    日期: 2014-03
    上傳時間: 2015-05-06 21:24:19 (UTC+8)
    出版者: Amer Chemical Soc
    摘要: A facile genetic methodology in the filamentous fungus Aspergillus nidulans allowed exchange of the starter unit ACP transacylase (SAT) domain in the nonreduced polyketide synthase (NR-PKS) AfoE of the asperfuranone pathway with the SAT domains from 10 other NR-PKSs. The newly created hybrid with the NR-PKS AN3386 is able to accept a longer starter unit in place of the native substrate to create a novel aromatic polyketide in vivo.
    關聯: Organic Letters, v.16 n.6, pp.1676-1679
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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