Protective effects of an aqueous Pericarpium Granati extract against inflammatory damage in mice

doi:10.1016/j.jff.2014.04.022

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Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28658

Title:	Protective effects of an aqueous Pericarpium Granati extract against inflammatory damage in mice
Authors:	Wang, Bor-Sen Leu, Kuen-Lin Huang, Guan-Jhong Yeh, Ching-Fen Tai, Huo-Mu Ho, Wen-Yueh Huang, Ming-Hsing
Contributors:	生活應用與保健系化粧品應用與管理系
Keywords:	Pericarpium Granati HPLC Polyphenolic Carrageenan Anti-inflammatory
Date:	2014-07
Issue Date:	2015-05-06 21:24:09 (UTC+8)
Publisher:	Elsevier Science Bv
Abstract:	The protective effect of an aqueous Pericarpium Granati extract (APG) against carrageenan-induced inflammatory damage in mice was investigated. The results showed that APG displayed radical scavenging, reducing activity, and liposome protection activity in acellular systems. The implementation of an HPLC helped identify polyphenolic components including epicatechin (11.9 mg/g), gallic acid (3.9 mg/g), ellagic acid (2.4 mg/g), ferulic acid (1.0 mg/g), quercetin (0.7 mg/g), and kaempferol (0.5 mg/g). APG administration in the range of 0.25-1.0 g/kg showed a concentration dependent inhibition on inflammatory response in carrageenan induced mice. The anti-inflammatory effects of APG could be related to the suppression of tissue nitric oxide and tumor necrosis factor-alpha, and associated with the reduction of lipid peroxidation and an increase in antioxidant enzyme activities including catalase, superoxide dismutase, and glutathione peroxidase in vivo. The results showed that APG might serve as a natural source of anti-inflammatory and antioxidative compounds in vivo. (C) 2014 Elsevier Ltd. All rights reserved.
Relation:	Journal of Functional Foods, v.9, pp.183-191
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles [Dept. of Life and Health Science] Periodical Articles

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