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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28640


    標題: Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma
    作者: Lee, Sung-Wei
    Lin, Ching-Yih
    Tian, Yu-Feng
    Sun, Ding-Ping
    Lin, Li-Ching
    Chen, Li-Tzong
    Hsing, Chung-Hsi
    Huang, Chiang-Ting
    Hsu, Han-Ping
    Huang, Hsuan-Ying
    Wu, Li-Ching
    Li, Chien-Feng
    Shiue, Yow-Ling
    貢獻者: 保健營養系
    關鍵字: Nasopharyngeal carcinoma
    CDC28 protein kinase regulatory subunit 1B
    CKS1B
    survival
    日期: 2014-03
    上傳時間: 2015-05-06 21:23:30 (UTC+8)
    出版者: Wiley-Blackwell
    摘要: Data mining on public domain identified that CDC28 protein kinase regulatory subunit 1B (CKS1B) transcript was highly expressed in nasopharyngeal carcinoma (NPC). The expression of CKS1B protein and its clinicopathological associations in patients with NPC were further evaluated. Immunoexpression of CKS1B was retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The correlations between CKS1B immunoexpression levels and clinicopathological features, as well as patient survivals, were analyzed. High CKS1B expression (49.2%) was correlated with the 7th American Joint Committee on Cancer (AJCC) stage (p=0.014). In multivariate analyses, high CKS1B expression emerged as an independent prognostic factor for worse disease-specific survival (p<0.001), metastasis-free survival (p<0.001), and local recurrence-free survival (p=0.001). High expression of CKS1B is common and associated with adverse prognostic factors and might confer tumor aggressiveness through dysregulation of the cyclin-dependent protein kinase (intrinsic regulatory activity) during cell cycle progression.
    關聯: Apmis, v.122 n.3, pp.206-214
    Appears in Collections:[保健營養系(所) ] 期刊論文

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