Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28628
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18034/20233 (89%)
Visitors : 23369740      Online Users : 527
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28628


    Title: N-Acetylcysteine Attenuates Hexavalent Chromium-Induced Hypersensitivity through Inhibition of Cell Death, ROS-Related Signaling and Cytokine Expression
    Authors: Lee, Yu-Hsuan
    Su, Shih-Bin
    Huang, Chien-Cheng
    Sheu, Hamm-Ming
    Tsai, Jui-Chen
    Lin, Chia-Ho
    Wang, Ying-Jan
    Wang, Bour-Jr
    Contributors: 化粧品應用與管理系
    Keywords: TUMOR-NECROSIS-FACTOR
    KAPPA-B
    OXIDATIVE STRESS
    MOLECULAR-MECHANISMS
    ARSENIC TRIOXIDE
    REDOX REGULATION
    SKIN-DISEASE
    CANCER-CELLS
    FACTOR-ALPHA
    TNF-ALPHA
    Date: 2014-09
    Issue Date: 2015-05-06 21:23:03 (UTC+8)
    Publisher: Public Library Science
    Abstract: Chromium hypersensitivity (chromium-induced allergic contact dermatitis) is an important issue in occupational skin disease. Hexavalent chromium (Cr(VI)) can activate the Akt, Nuclear factor kappa B (NF-kappa B), and Mitogen-activated protein kinase (MAPK) pathways and induce cell death, via the effects of reactive oxygen species (ROS). Recently, cell death stimuli have been proposed to regulate the release of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1). However, the exact effects of ROS on the signaling molecules and cytotoxicity involved in Cr(VI)-induced hypersensitivity have not yet been fully demonstrated. N-acetylcysteine (NAC) could increase glutathione levels in the skin and act as an antioxidant. In this study, we investigated the effects of NAC on attenuating the Cr(VI)-triggered ROS signaling in both normal keratinocyte cells (HaCaT cells) and a guinea pig (GP) model. The results showed the induction of apoptosis, autophagy and ROS were observed after different concentrations of Cr(VI) treatment. HaCaT cells pretreated with NAC exhibited a decrease in apoptosis and autophagy, which could affect cell viability. In addition, Cr (VI) activated the Akt, NF-kappa B and MAPK pathways thereby increasing IL-1 alpha and TNF-alpha production. However, all of these stimulation phenomena could be inhibited by NAC in both of in vitro and in vivo studies. These novel findings indicate that NAC may prevent the development of chromium hypersensitivity by inhibiting of ROS-induced cell death and cytokine expression.
    Relation: Plos One, v.9 n.9, e108317
    Appears in Collections:[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML1566View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback