Increased Lung Cancer Risk Among Patients with Pneumococcal Pneumonia: A Nationwide Population-Based Cohort Study

doi:10.1007/s00408-013-9523-z

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Title:	Increased Lung Cancer Risk Among Patients with Pneumococcal Pneumonia: A Nationwide Population-Based Cohort Study
Authors:	Lin, Te-Yu Huang, Wen-Yen Lin, Jung-Chung Lin, Cheng-Li Sung, Fung-Chang Kao, Chia-Hung Yeh, Jun-Jun
Contributors:	嬰幼兒保育系
Keywords:	Pneumococcal pneumonia Lung cancer Nationwide population-based Cohort study Taiwan National Health Insurance Database
Date:	2014-02
Issue Date:	2015-05-06 21:22:07 (UTC+8)
Publisher:	Springer
Abstract:	The possible effects of pneumonia on subsequent lung cancer have been reported, but no relevant publications have focused on the association between pneumococcal pneumonia and lung cancer. The purpose of this study was to perform a nationwide population-based cohort study to investigate the risk of lung cancer after pneumococcus infection. This nationwide population-based cohort study was based on data obtained from the Taiwan National Health Insurance Database. In total, 22,034 pneumococcal pneumonia patients and 88,136 controls, matched for age and sex, were recruited for the study from 1997 to 2010. The incidence rate of lung cancer (28.2 per 1,000 person-years) was significantly higher in pneumococcal pneumonia patients than in controls (8.7 per 1,000 person-years; incidence rate ratio, 3.25; 95 % confidence interval, 3.09-3.42; p < 0.001). Cox proportional hazards regression analysis showed a hazard ratio of 4.24 (95 % confidence interval, 3.96-4.55) for the pneumococcal pneumonia cohort after adjustment for age, gender, and comorbidities. Pneumococcal pneumonia is associated with an increased risk of lung cancer. Thus, physicians should remain aware of this association when assessing patients with pneumococcal pneumonia.
Relation:	Lung, v.192 n.1, pp.159-165
Appears in Collections:	[Dept. of Childhood Education and Nursery] Periodical Articles

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