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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28595

    標題: Hypercholesterolemia Is Correlated With an Increased Risk of Idiopathic Sudden Sensorineural Hearing Loss: A Historical Prospective Cohort Study
    作者: Chang, Shih-Lun
    Hsieh, Chen-Chou
    Tseng, Kuo-Shu
    Weng, Shih-Feng
    Lin, Yung-Song
    貢獻者: 醫務管理系
    關鍵字: Idiopathic sudden sensorineural hearing loss
    Coronary arterial disease
    日期: 2014-03
    上傳時間: 2015-05-06 21:21:55 (UTC+8)
    出版者: Lippincott Williams & Wilkins
    摘要: Objective: Despite the many studies on the associated risk of cardiovascular and cerebrovascular events in patients with hypercholesterolemia (HCh), an association between HCh and the development of idiopathic sudden sensorineural hearing loss (ISSNHL) has been examined in only a few case-control studies. We tested the hypothesis that HCh is a risk factor for developing ISSNHL. Design: Using the Taiwan Longitudinal Health Insurance Database, we conducted a historical prospective cohort study to compare patients diagnosed with HCh from January 1, 2001, through to December 31, 2006 (N = 73,957) with age-matched controls (N = 73,957). We followed each patient until the end of 2009 and evaluated the incidence of ISSNHL for a minimum of 3 years after the initial HCh diagnosis. Results: The incidence of ISSNHL was 1.62 times higher in the HCh cohort than in the non-HCh cohort (10.67 versus 6.61 per 10,000 person-years). Using Cox proportional hazard regressions, the adjusted hazard ratio was 1.60 (95% confidence interval [CI] = 1.39-1.85). An increased risk of developing ISSNHL, with adjusted hazard ratios of 1.48 (95% CI = 1.08-2.04) and 1.69 (95% CI = 1.18-2.43), was observed in HCh patients with newly diagnosed comorbidities of stroke or stroke combined with coronary artery diseases, which are both expected to reflect the severity of HCh. Conclusions: A diagnosis of HCh may indicate an independent risk for ISSNHL. This finding suggests that an underlying vascular mechanism contributes to the development of ISSNHL. We suggest that physicians counsel patients with HCh to seek medical attention if they have hearing impairments, because they may also have an increased risk of developing ISSNHL.
    關聯: Ear and Hearing, v.35 n.2, pp.256-261
    Appears in Collections:[醫務管理系(所)] 期刊論文

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