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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28592


    標題: Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats
    作者: Hsu, Chuan-Chih
    Chen, Li-Fan
    Lin, Mao-Tsun
    Tian, Yu-Feng
    貢獻者: 保健營養系
    關鍵字: HEAT-STROKE
    MAGNOLIA-OFFICINALIS
    EFFECTIVE INHIBITION
    BIPHENYL COMPOUNDS
    CEREBRAL-ISCHEMIA
    DYSFUNCTION
    DAMAGE
    CELLS
    日期: 2014
    上傳時間: 2015-05-06 21:21:50 (UTC+8)
    出版者: Hindawi Publishing Corporation
    摘要: We aimed at investigating the effect of honokiol on heatstroke in an experimental rat model. Sprogue-Dawley rats were divided into 3 groups: normothermic diabetic rats treated with vehicle solution (NTDR+V), heatstroke-diabetic rats treated with vehicle (HSDR+V), and heatstroke rats treated with konokiol (0.5-5mg/ml/kg) (HSDR+H). Sixty minutes before the start of heat stress, honokiol or vehicle solution was administered. (HSDR+H) significantly (a) attenuated hyperthermia, hypotension and hypothalamic ischemia, hypoxia, and neuronal apoptosis; (b) reduced the plasma index of the toxic oxidizing radicals; (c) diminished the indices of hepatic and renal dysfunction; (d) attenuated the plasma systemic inflammatory response molecules; (e) promoted plasma levels of an anti-inflammatory cytokine; (f) reduced the index of infiltration of polymorphonuclear neutrophils in the serum; and (g) promoted the survival time fourfold compared with the (HSDR+V) group. In conclusion, honokiol protected against the outcome of heatstroke by reducing inflammation and oxidative stress-mediated multiple organ dysfunction in diabetic rats.
    Appears in Collections:[保健營養系(所) ] 期刊論文

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