High hepatitis B virus surface antigen levels and favorable interleukin 28B genotype predict spontaneous hepatitis C virus clearance in uremic patients

doi:10.1016/j.jhep.2013.09.023

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標題:	High hepatitis B virus surface antigen levels and favorable interleukin 28B genotype predict spontaneous hepatitis C virus clearance in uremic patients
作者:	Yu, Ming-Lung Dai, Chia-Yen Huang, Chung-Feng Lee, Jia-Jung Yeh, Ming-Lun Yeh, Shih-Meng Kuo, Hsing-Tao Huang, Jee-Fu Chang, Jer-Ming Chen, Hung-Chun Juo, Suh-Hang Hank Hwang, Shang-Jyh Chuang, Wan-Long
貢獻者:	老人服務事業管理系
關鍵字:	IL-28B HCV HBsAg level Spontaneous clearance Uremia
日期:	2014-02
上傳時間:	2015-05-06 21:21:44 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	Background & Aims: Host and viral factors interplay in the spontaneous clearance of hepatitis C virus (HCV) infection. We aimed to explore the roles of IL28B genotypes and hepatitis B virus (HBV) infections in spontaneous HCV seroclearance. Methods: IL28B rs8099917 genotypes, HCV and HBV markers were determined in 290 patients who were seropositive for HCV antibodies from 1681 total uremic patients on maintenance hemodialysis. Results: Persistent HCV viremia was observed in 74.6% (214/287) of patients. Logistic regression revealed that the strongest factors associated with spontaneous HCV seroclearance were carriage of rs8099917 TT-type (odds ratio/95% confidence intervals [ OR/CI]: 6.22/1.41-27.35, p = 0.016), followed by concurrent hepatitis B surface antigen (HBsAg) seropositivity (OR/CI: 2.37/1.06-5.26, p = 0.035). The clearance rate was highest among patients with both positive HBsAg/rs8099917 TT-type (44.8%, OR/CI: 20.88/ 3.5-402.5), followed by positive HBsAg/rs8099917 non-TT-type (28.6%, OR/CI: 8.86/1.8-160.8), and negative HBsAg/rs8099917 TT-type (26.7%, OR/CI: 12.75/1.0-319.4), compared to 4% of negative HBsAg/rs8099917 non-TT-type (trend p = 0.0002). HBsAg levels, but not HBV DNA levels, were significantly associated with spontaneous HCV seroclearance. Spontaneous HCV seroclearance rate was 58.3% in patients with HBsAg > 200 IU/ml/rs8099917 TTtype (OR/CI: 42.54/5.7-908.4), 28.0% in patients with HBsAg < 200 IU/ml/rs8099917 TT-type or HBsAg > 200 IU/ml/ rs8099917 non-TT-type (OR/CI: 11.12/2.3-201.0), compared to only 3.3% in those with HBsAg < 200 IU/ml/rs8099917 non-TTtype (trend p = 0.0004). Five of 214 (2.3%) HCV viremic patients at enrollment had spontaneous HCV seroclearance during oneyear follow-up, which was associated with baseline HCV RNA and HBsAg levels. Conclusions: High HBsAg levels and favorable IL28B genotype were additively associated with spontaneous HCV seroclearance in uremic patients. (C) 2013 European Association for the Study of the Liver. Published by Elsevier B. V. All rights reserved.
關聯:	Journal of Hepatology, v.60 n.2, pp.253-259
显示于类别:	[高齡福祉養生管理系] 期刊論文

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