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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28586


    標題: Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan
    作者: Jiang, Yi-Der
    Chuang, Lee-Ming
    Pei, Dee
    Lee, Yann-Jinn
    Wei, Jun-Nan
    Sung, Fung-Chang
    Chang, Tien-Jyun
    貢獻者: 職業安全衛生系
    關鍵字: GENOME-WIDE ASSOCIATION
    HOMEOSTASIS MODEL ASSESSMENT
    BETA-CELL
    CLINICAL CHARACTERISTICS
    E23K POLYMORPHISM
    YOUTH PREVALENCE
    K+ CHANNEL
    FAMILIAL HYPERINSULINISM
    JAPANESE POPULATION
    SUR1 ABCC8
    日期: 2014
    上傳時間: 2015-05-06 21:21:36 (UTC+8)
    出版者: Hindawi Publishing Corporation
    摘要: To investigate the role of E23K polymorphism of the KCNJ11 gene on early onset of type 2 diabetes in school-aged children/adolescents in Taiwan, we recruited 38 subjects with type 2 diabetes (ages 18.6 +/- 6.6 years; body mass index percentiles 83.3 +/- 15.4) and 69 normal controls (ages 17.3 +/- 3.8 years; body mass index percentiles 56.7 +/- 29.0) from a national surveillance for childhood/adolescent diabetes in Taiwan. We searched for the E23K polymorphism of the KCNJ11 gene. We found that type 2 diabetic subjects had higher carrier rate of E23K polymorphism of KCNJ11 gene than control subjects (P - 0.044). After adjusting for age, gender, body mass index percentiles, and fasting plasma insulin, the E23K polymorphism contributed to an increased risk for type 2 diabetes (P = 0.047). K23-allele-containing genotypes conferring increased plasma insulin level during OGTT in normal subjects. However, the diabetic subjects with the K23-allele-containing genotypes had lower fasting plasma insulin levels after adjustment of age and BMI percentiles. In conclusion, the E23K variant of the KCNJ11 gene conferred higher susceptibility to type 2 diabetes in children/adolescents. Furthermore, in normal glucose-tolerant children/adolescents, K23 allele carriers had a higher insulin response to oral glucose loading.
    Appears in Collections:[職業安全衛生系(含防災所)] 期刊論文

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