Genetic Background Influences Nicotine-induced Conditioned Place Preference and Place Aversion in Mice

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Title:	Genetic Background Influences Nicotine-induced Conditioned Place Preference and Place Aversion in Mice
Authors:	Ise, Yuya Mori, Tomohisa Katayama, Shirou Suzuki, Tsutomu Wang, Tzu-Chueh
Contributors:	藥學系
Keywords:	conditioned place preference paradigm nicotine mecamylamine genetic difference mice
Date:	2014-02
Issue Date:	2015-05-06 21:21:34 (UTC+8)
Publisher:	Medical Assoc Nippon Medical Sch
Abstract:	This study was designed to determine whether genetic differences influence the rewarding effects of nicotine in 4 inbred strains of mice (DBA/2, BALB/c, C3H, and C57BL/6). Nicotine (subcutaneous) induced a place preference in DBA/2 and BALB/c mice but a place aversion in C57BL/6 mice. A low dose of nicotine produced a significant place preference, whereas a high dose of nicotine produced place aversion in C3H mice. These effects were completely reversed by the nicotinic receptor antagonist mecamylamine. These results strongly suggest that a conditioned state, such as rewarding effects or aversive effects, can be influenced by genetic background.
Relation:	Journal of Nippon Medical School, v.81 n.1, pp.53-56
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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