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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28585


    標題: Genetic Background Influences Nicotine-induced Conditioned Place Preference and Place Aversion in Mice
    作者: Ise, Yuya
    Mori, Tomohisa
    Katayama, Shirou
    Suzuki, Tsutomu
    Wang, Tzu-Chueh
    貢獻者: 藥學系
    關鍵字: conditioned place preference paradigm
    nicotine
    mecamylamine
    genetic difference
    mice
    日期: 2014-02
    上傳時間: 2015-05-06 21:21:34 (UTC+8)
    出版者: Medical Assoc Nippon Medical Sch
    摘要: This study was designed to determine whether genetic differences influence the rewarding effects of nicotine in 4 inbred strains of mice (DBA/2, BALB/c, C3H, and C57BL/6). Nicotine (subcutaneous) induced a place preference in DBA/2 and BALB/c mice but a place aversion in C57BL/6 mice. A low dose of nicotine produced a significant place preference, whereas a high dose of nicotine produced place aversion in C3H mice. These effects were completely reversed by the nicotinic receptor antagonist mecamylamine. These results strongly suggest that a conditioned state, such as rewarding effects or aversive effects, can be influenced by genetic background.
    關聯: Journal of Nippon Medical School, v.81 n.1, pp.53-56
    Appears in Collections:[藥學系(所)] 期刊論文

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