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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28552


    標題: Effects of Garlic Oil on Interleukin-6 Mediated Cardiac Hypertrophy in Hypercholesterol-Fed Hamsters
    作者: Hsieh, You-Liang
    Pai, Peiying
    Ho, Tsung-Jung
    Chung, Li-Chin
    Cheng, Yi-Chang
    Wu, Chieh-Hsi
    Fan, Ming-Jen
    Day, Cecilia Hsuan
    Shen, Chia-Yao
    Huang, Chih-Yang
    貢獻者: 醫務管理系
    關鍵字: garlic oil
    heart
    hypercholesterol
    hypertrophy
    日期: 2014-12
    上傳時間: 2015-05-06 21:20:26 (UTC+8)
    出版者: Chinese Physiological Soc
    摘要: Hypercholesterol diets are the major causes of cardiac hypertrophy and various cardiac disorders. The purpose of this study is to evaluate the effects of garlic oil on cardiac hypertrophy induced by hypercholesterol diets. Golden Syrian hamsters were fed with 2% cholesterol or 2% cholesterol plus 1% garlic oil for 2 months. Heart architecture changes were measured by hematoxylin-eosin staining and the molecular mechanism was determined by western blotting. Garlic oil reduced whole-heart weight to bone weight ratio, and left ventricle weight to bone weight ratio in the cholesterol-fed group. Moreover, the garlic oil group showed significantly reduced interleukin-6, phosphorylated (p)-extracellular signal-regulated kinase-5, p-mitogen-activated protein kinase-5, calcineurin, nuclear transcription factor of nuclear factor of activated T-cells-3 and p-GATA binding protein 4 when compared with the cholesterol group. However, no changes were observed in gp-130, signal transducer and activator of transcription-3, p-P38 and p-Jun N-terminal kinases protein levels in all groups. The results show that garlic oil may be useful in the treatment of hypertrophy-associated cardiovascular diseases.
    關聯: Chinese Journal of Physiology, v.57 n.6, pp.320-328
    Appears in Collections:[醫務管理系(所)] 期刊論文

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