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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28537


    標題: Cytomegalovirus colitis in intensive care unit patients: Difficulties in clinical diagnosis.
    作者: Chan, Khee-Siang
    Yang, Chun-Chieh
    Chen, Chin-Ming
    Yang, His-Hsing
    Lee, Ching-Chien
    Chuang, Yin-Ching
    Yu, Wen-Liang
    貢獻者: 保健營養系
    關鍵字: Cytomegalovirus colitis
    Acute hemorrhagic rectal ulcer
    Immunohistochemical stain
    Polymerase chain reaction
    Pseudomembranous colitis
    日期: 2014-06
    上傳時間: 2015-05-06 21:19:50 (UTC+8)
    出版者: W B Saunders Co-Elsevier Inc
    摘要: Purpose: Cytomegalovirus (CMV) infection occurs increasingly in critically ill patients in intensive care units (ICUs). We reported CMV colitis which has rarely been recognized in the ICU patients. Methods: CMV DNA was detected by polymerase chain reaction (PCR) for blood and/or stool samples. Definite diagnosis of CMV colitis required histopathology or CMV immunohistochemical staining of colorectal biopsies. We reviewed ICU patients characterized by positiveblood or stool CMV-PCR with colorectal bleeding or water diarrhea. Results: We identified 18 patients (biopsy-proved, n = 8; probable cases, n = 10). The most common comorbidities were chronic renal disease, diabetes mellitus, and coronary artery disease. Stool CMV-PCR was positive in 7 of 10 patients (2 of 3 biopsy-proved and 5 of 7 probable cases). Colonoscopy was performed for 15 patients, revealing ulcerative or polypoid lesions. The endoscopists obtained colonic biopsies from 9 patients. Yet, the pathologists reported CMV colitis for 4 patients. Additional 4 patients were confirmed using immunohistochemical stain by the request of clinical physicians. Pseudomembranous colitis was found in 4 patients. Conclusion: Diagnosis of CMV colitis seems difficult in clinical practice and need persistent communication between clinicians. The positive stool CMV-PCR result was a useful hint for adding immunohistochemical stain in mucosal biopsies to make a definite diagnosis of CMV colitis. (C) 2014 Elsevier Inc. All rights reserved.
    關聯: Journal of Critical Care, v.29 n.3, 4740
    Appears in Collections:[保健營養系(所) ] 期刊論文

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