English  |  正體中文  |  简体中文  |  Items with full text/Total items : 16812/19099 (88%)
Visitors : 6362678      Online Users : 316
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28531


    標題: Constituents of the Roots of Clausena lansium and Their Potential Anti-inflammatory Activity
    作者: Shen, De-Yang
    Chan, Yu-Yi
    Hwang, Tson-Long
    Juang, Shin-Hun
    Huang, Shiow-Chyn
    Kuo, Ping-Chung
    Thang, Tran Dinh
    Lee, E-Jian
    Damu, Amooru G.
    Wu, Tian-Shung
    貢獻者: 藥學系
    關鍵字: CARBAZOLE ALKALOIDS
    EXCAVATA
    DERIVATIVES
    COUMARINS
    HARMANDIANA
    PRINCIPLES
    ANISATA
    LEAVES
    STEMS
    BARKS
    日期: 2014-05
    上傳時間: 2015-05-06 21:19:38 (UTC+8)
    出版者: Amer Chemical Soc
    摘要: Eight new carbazole alkaloids, claulamines C (1), D (2), and E (5) and clausenalines B-F (3, 4, 6-8), four new coumarins, clausemarins A-D (9-12), and 43 known compounds were isolated from the roots of Clausena lansium. The structures of the new compounds were established on the basis of 2D-NMR spectroscopic analysis, and their absolute configurations were established from their ECD spectra. The configuration of wampetin was revised as E using a NOESY experiment. Most of the isolated compounds were evaluated for their potential anti-inflammatory activity. The results showed that compounds 9, 13-18, and 20-22 exhibited strong inhibition of superoxide anion generation with IC50 values ranging from 1.9 to 8.4 mu M, while compounds 18, 19, and 21 inhibited elastase release with IC50 values in the range from 2.0 to 6.9 mu M.
    關聯: Journal of Natural Products, v.77 n.5, pp.1215-1223
    Appears in Collections:[藥學系(所)] 期刊論文

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML396View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback