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    標題: Co-administration of memantine with epinephrine produces a marked peripheral action in intensifying and prolonging analgesia in response to local skin pinprick in rats
    作者: Chen, Yu-Wen
    Tzeng, Jann-Inn
    Pan, He-Jia
    Hung, Ching-Hsia
    Chen, Yu-Chung
    Wang, Jhi-Joung
    貢獻者: 食品科技系
    關鍵字: Epinephrine
    Memantine
    Lidocaine
    Subcutaneous injection
    Local anesthetic
    Cutaneous analgesia
    日期: 2014-06
    上傳時間: 2015-05-06 21:19:33 (UTC+8)
    出版者: Elsevier Ireland Ltd
    摘要: The purpose of this study was to examine the effect of epinephrine as adjuvant for memantine or lidocaine as an infiltrative anesthetic. Using a rat model of cutaneous trunci muscle reflex (CTMR), we evaluated the effects of adding epinephrine to memantine or lidocaine on infiltrative cutaneous analgesia. Lidocaine, a known local anesthetic, was used as control. We found that epinephrine, memantine, and lidocaine produced a dose-dependent local anesthetic effect as infiltrative cutaneous analgesia. On a 50% effective dose (ED50) basis, the relative potencies were epinephrine [0.012(0.006-0.020) mu mol] > memantine [4.010 (3.311-4.988) mu mol] > lidocaine [6.177 (5.333-7.218) mu mol] (P<0.05 for each comparison). Mixtures of epinephrine (2.7 nmol or 13.7 nmol) with drugs (memantine or lidocaine) at ED50 or ED95, respectively, enhanced the potency and prolonged the duration of action on infiltrative cutaneous analgesia. Intraperitoneal injection of co-administration of drugs (memantine or lidocaine) at ED95 with epinephrine (13.7 nmol) produced no cutaneous analgesia (data not shown). Epinephrine, memantine, and lidocaine were shown to have local anesthetic effects as infiltrative cutaneous analgesia. Epinephrine increased the duration and potency of memantine and lidocaine as an infiltrative anesthetic. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
    關聯: Neuroscience Letters, v.574, pp.59-63
    顯示於類別:[ 食品科技系 ] 期刊論文

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