Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28518
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    標題: Baicalein Inhibits HMGB1 Release and MMP-2/-9 Expression in Lipopolysaccharide-Induced Cardiac Hypertrophy
    作者: Chen, Huai-Min
    Liou, Shu-Fen
    Hsu, Jong-Hau
    Chen, Tsan-Ju
    Cheng, Tsung-Lin
    Chiu, Chaw-Chi
    Yeh, Jwu-Lai
    貢獻者: 藥學系
    關鍵字: Baicalein
    Lipopolysaccharide
    Cardiac Hypertrophy
    Reactive Oxygen Species
    Matrix Metalloproteinases
    High Mobility Group Box 1
    日期: 2014
    上傳時間: 2015-05-06 21:19:10 (UTC+8)
    出版者: World Scientific Publ Co Pte Ltd
    摘要: Myocardial dysfunction, a common complication after sepsis, significantly contributes to the death of patients with septic shock. In the search for potentially effective drugs to decrease mortality from sepsis, we investigated the cardioprotective effects of baicalein, a flavonoid present in the root of Scutellaria baicalensis, on lipopolysaccharide (LPS)-induced pro-inflammatory cytokine production and matrix metalloproteinase-2 and -9 (MMP-2/-9) expression. We found that baicalein significantly attenuated LPS-induced cardiac hypertrophy and counteracted reactive oxygen species (ROS) generation in neonatal rat cardiomyocytes. In addition, pretreatment with baicalein inhibited LPS-induced early (e. g., tumor necrosis factor-alpha (TNF-alpha) and interleukin-6) and late (e.g., high mobility group box 1 (HMGB1) pro-inflammatory cytokine release, inducible nitric oxide synthase (iNOS) expression and NO production. Finally, baicalein also significantly down-regulated the expression of MMP-2/-9 and attenuated HMGB1 translocation from the nucleus to the cytoplasm. These results suggest that baicalein can protect cardiomyocytes from LPS-induced cardiac injury via the inhibition of ROS and inflammatory cytokine production. These cardioprotective effects are possibly mediated through the inhibition of the HMGB1 and MMP-2/-9 signaling pathways.
    關聯: American Journal of Chinese Medicine, v.42 n.4, pp.785-797
    显示于类别:[藥學系(所)] 期刊論文

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