Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28513
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    標題: Asthma increases pulmonary thromboembolism risk: a nationwide population cohort study
    作者: Chung, Wei-Sheng
    Lin, Cheng-Li
    Ho, Feng-Ming
    Li, Ruei-Yuan
    Sung, Fung-Chang
    Kao, Chia-Hung
    Yeh, Jun-Jun
    貢獻者: 嬰幼兒保育系
    關鍵字: DEEP-VEIN THROMBOSIS
    ENDOTHELIAL DYSFUNCTION
    VENOUS THROMBOEMBOLISM
    ALLERGEN CHALLENGE
    EMBOLISM
    COAGULATION
    COPD
    PREVALENCE
    MORTALITY
    DISEASE
    日期: 2014-03
    上傳時間: 2015-05-06 21:19:00 (UTC+8)
    出版者: European Respiratory Soc Journals Ltd
    摘要: Studies on the association between asthma and pulmonary thromboembolism are considerably limited. We investigated whether pulmonary embolism is associated with asthma using a nationwide cohort study. We identified 31 356 patients with newly diagnosed asthma in 2002-2008 and 125 157 individuals without asthma randomly selected from the general population, frequency matched by age, sex and index year using the National Health Insurance Research Database. Both cohorts were followed-up until the end of 2010 to measure the incidence of pulmonary embolism. Cox proportional hazards regression analysis was used to measure the hazard ratio of pulmonary embolism for the asthmatic cohort, compared with the nonasthmatic cohort. We followed 186 182 person-years for asthmatic patients and 743 374 person-years for nonasthmatic subjects. The hazard ratio of pulmonary embolism was 3.24 for the asthmatic cohort, compared with the nonasthmatic cohort after adjusting for sex, age, comorbidities and oestrogen supplementation. The risk of developing pulmonary embolism significantly increased with the increased frequency of asthma exacerbation and hospitalisation. This nationwide cohort study suggests that the risk of developing pulmonary embolism is significantly increased in asthmatic patients compared to the general population. Frequent asthma exacerbation and hospitalisation are significantly associated with pulmonary embolism risk.
    關聯: European Respiratory Journal, v.43 n.3, pp.801-807
    显示于类别:[嬰幼兒保育系] 期刊論文

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