Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28491
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    標題: A Novel Route for Preparation of Multifunctional Polymeric Nanocarriers for Stimuli-Triggered Drug Release
    作者: Kuo, Chih-Yu
    Wang, Yu-Cheng
    Lee, Chia-Fen
    Chiu, Wen-Yen
    貢獻者: 化粧品應用與管理系
    關鍵字: addition fragmentation chain-transfer (RAFT)
    controlled release
    nanoparticles
    poly(N-isopropylacrylamide)
    reversible
    self-assembly
    日期: 2014-02
    上傳時間: 2015-05-06 21:18:12 (UTC+8)
    出版者: Wiley-Blackwell
    摘要: Fluorescence-incorporated, crosslinker-free, pH- and thermoresponsive nanocarriers were prepared by the incorporation of drug molecules into the thermoresponsive nanocapsules, which composed of poly(N-isopropylacrylamide) (PNIPAAm) with carboxylic acid end groups via temperature induced self-assembling method. Well-defined, pH-responsive carboxylic acid group-ended PNIPAAm homopolymer (HOOCPNIPAAmCOOH) was synthesized by reversible addition fragmentation chain transfer polymerization with S,S-bis(,-dimethyl--acetic acid)trithiocarbonate (CMP) as a chain transfer agent. Rhodamine 6G (R6G), the model drug, was used for three kinds of application: First, the nanostructure fixing; second, the fluorescence-labeling; and last, the controlled release modeling. The transmission electron microscope images showed the solution type dosing led to the encapsulation of drug molecules into the nanocarriers, while the powder-type drug-loading process significantly contributed to the structure preservation of nanocarriers. The controlled release behaviors with various pH values and temperatures were evaluated. These multifunctional nanocarriers have potential to be applied for the biomedical therapy by stimuli-responsive controlled release. (c) 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 561-571
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