A Study of Cardiotoxic Principles From The Venom of Bungarus Fasc1Atus (Schneider)

Chia Nan University of Pharmacy & Science Institutional Repository > 嘉南學報 > 1期 (1975) > Item 310902800/28423

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/28423

標題:	A Study of Cardiotoxic Principles From The Venom of Bungarus Fasc1Atus (Schneider)
作者:	SHOEI-YN SHIAU LIN MEI-CHIAU HUANG C. Y. LEE
貢獻者:	私立嘉南藥學專科學校
日期:	1975
上傳時間:	2014-12-26 11:48:33 (UTC+8)
摘要:	It is well known that all of the elapid venoms contain neurotoxins which are the major principles causing death in animals. Neurotoxins of the venom of Bungarus fasciatus have?been isolated (GHOSH et al.,1939; MOORE and LOY, 1972; LIN SHAIU et al.,1972).In addition to neurotoxins, cobra venom also contains cardiotoxins which are responsible for the circulatory effects as well as for the local actions such as pain, edema and muscle degeneration?(LEE et al.,1968; LAI et., 1972). The venom of Binearus multicinctus contains no such cardictoxin-like principle and does not cause local actions. Although Bungarus fasciatus belongs to the same genus as Bungarus multicinctus, the venom of the former?causes local actions. Hence, it was considered that the venom of Bungarus fasciatus might contain cardiotoxin-like principles. The result described in this paper verified this hypothesis. The pharmxcological properties of cobra cardiotoxin have been extensively studied (LEE et al., 1968 ,1972; CHANG et al., 1972). This toxin affects various kinds of cells to produce skeletal muscle contracture, smooth muscle contraction, local irritation, direct hemolysis and cytotoxic action on HeLa, KB and Yoshida sarcoma cells. In this paper, a comparative study on the chemical and pharmacologicalproperties of the isolated cardio-toxin-like principles from Bungarus fasciatus and cobra venom are described.
關聯:	嘉南學報, n.1 pp.118-130 轉載
显示于类别:	[嘉南學報] 1期 (1975)

文件中的档案:

没有与此文件相关的档案.

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....