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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28317

    標題: 鯖魚生物活性胜肽對黑色素合成、肝臟細胞氧化與內皮細胞發炎之抑制作用
    Inhibitory Effects of Bioactive Peptides from Mackerel on Melanin Production, Hepatocyte Oxidative Damage and Endothelial Inflammation
    作者: 王柏森
    貢獻者: 嘉南藥理大學生活應用與保健系
    日期: 2013
    上傳時間: 2014-11-05 15:31:46 (UTC+8)
    摘要: In this project, the major purpose is to investigate of inhibitory effects of bioactive peptides from mackerel on melanin production, hepatocyte oxidative damage and endothelial inflammation. The goal of the first year is to investigate the regulatory effects of bioactive peptides from mackerel on melanin production in B16 cells.However, in this study, the antioxidant and antityrosinase activities of bioactive peptides from mackerel were determined. The antioxidant activities were carried out using different in vitro assays including the inhibition of ABTS and the chelating activity. Bioactive peptides from mackerel displayed antioxidant and antityrosinase activities. In addition, bioactive peptides B2, B4, C2 from mackerel decreased tyrosinase expression in B16 cells. bioactive peptides B2, B4, C2 from mackerel also decrease the levels of TRP-1 and TRP-2 in B16 cells. These data suggested that bioactive peptides B2, B4, C2 from mackerel exhibiting biological activities could contribute to antimelanogenesis as well as antioxidation.
    關聯: 計畫編號:NSC101-2313-B041-001-MY3
    Appears in Collections:[生活應用與保健系] 國科會計畫

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