Relationships between changes in leptin and insulin resistance levels in obese individuals following weight loss

doi:10.1016/j.kjms.2012.08.041

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/27912

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27912

Title:	Relationships between changes in leptin and insulin resistance levels in obese individuals following weight loss
Authors:	Wang, Tsu-Nai Chang, Wen-Tsan Chiu, Yu-Wen Lee, Chun-Ying Lin, Kun-Der Cheng, Yu Yao Su, Yi-Ju Chung, Hsin-Fang Huang, Meng-Chuan
Contributors:	保健營養系
Keywords:	Ghrelin Insulin Resistance Leptin Polyunsaturates Weight Control
Date:	2013-08
Issue Date:	2014-05-26 10:48:44 (UTC+8)
Publisher:	Elsevier Taiwan
Abstract:	Obesity can augment insulin resistance (IR), leading to increased risk of diabetes and heart disease. Leptin, ghrelin, and various fatty acids present in the cell membrane may modulate IR. In this study, we aimed to investigate the impact of weight loss on IR, serum leptin/ghrelin levels, and erythrocyte fatty acids, and studied the associations between changes in these variables. A total of 35 obese (body mass index >= 27) adults participated in a weight loss program for 3 months. IR was assessed using homeostasis model assessment for insulin resistance (HOMA-IR). The obese participants had a mean weight loss of 5.6 +/- 3.8 kg followed by a 16.7% and 23.3% reduction in HOMA-IR and leptin (p < 0.001) levels, and an 11.3% increase in ghrelin levels (p = 0.005). The level of erythrocyte saturates decreased by 2.8%, while the level of n-3 polyunsaturates increased by 16.8% (all p < 0.05). The changes in leptin levels (-5.63 vs. -1.57 ng/mL) were significantly different (p = 0.004) in those with improved IR (changes in HOMA-IR < 0) than those without improvement (changes in HOMA-IR >= 0), though there were no differences in the changes of ghrelin (p = 0.120) and erythrocyte fatty acids (all p > 0.05) levels. After adjusting for age, gender, changes in ghrelin, and body fat, we found a significant correlation between decreases in leptin and less risk of no improvement in HOMA-IR levels [odds ratio (OR) = 0.69, p = 0.039]. In conclusion, a moderate weight reduction in obese participants over a short period significantly improved IR. This weight reduction concomitantly decreased serum leptin, increased ghrelin, and elevated some erythrocyte unsaturates. Only leptin correlated independently with IR improvement upon multivariable logistic regression analysis, which indicates that leptin may play a role in the modulation of IR following weight loss. Copyright (c) 2012, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.
Relation:	Kaohsiung Journal of Medical Sciences, v.29 n.8, pp.436-443
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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