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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27911


    標題: Reconstitution of the early steps of gliotoxin biosynthesis in Aspergillus nidulans reveals the role of the monooxygenase GliC
    作者: Chang, Shu-Lin
    Chiang, Yi-Ming
    Yeh, Hsu-Hua
    Wu, Tung-Kung
    Wang, Clay C. C.
    貢獻者: 生物科技系
    藥學系
    關鍵字: Biosynthesis
    Gliotoxin
    Heterologous Expression
    日期: 2013-04
    上傳時間: 2014-05-26 10:48:42 (UTC+8)
    出版者: Pergamon-Elsevier Science Ltd
    摘要: The gliotoxin, a member of the epipolythiodioxopiperazine (ETP), has received considerable attention from the scientific community for its wide range of biological activity. Despite the identification of gliotoxin cluster, however, the sequence of steps in the gliotoxin biosynthesis has remained elusive. As an alternative to the gene knock-out and biochemical approaches used so far, here we report using a heterologous expression approach to determine the sequence of the early steps of gliotoxin biosynthesis in Aspergillus nidulans. We identified the GliC, a monooxygenases that involved in the second step of gliotoxin biosynthesis pathway through the catalyzing the hydroxylation at the alpha-position of L-Phe. (C) 2013 Elsevier Ltd. All rights reserved.
    關聯: Bioorganic & Medicinal Chemistry Letters, v.23 n.7, pp.2155-2157
    Appears in Collections:[生物科技系(所)] 期刊論文
    [藥學系(所)] 期刊論文

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