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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27899


    標題: Phellinus linteus polysaccharides and their immunomodulatory properties in human monocytic cells
    作者: Wu, Shu-Jing
    Liaw, Chih-Chuang
    Pan, Shin-Zon
    Yang, Hsing-Chia
    Ng, Lean-Teik
    貢獻者: 保健營養系
    關鍵字: Phellinus Linteus
    Polysaccharides
    Myd88
    Mapk
    Thp-1 Cells
    日期: 2013-04
    上傳時間: 2014-05-26 10:48:12 (UTC+8)
    出版者: Elsevier Science Bv
    摘要: Phellinus linteus (PL), a high value medicinal mushroom, is popularly consumed as traditional medicine and health foods for enhancing immune functions in Asia. This study aimed to examine the immunomodulating properties of aqueous (HPL) and ethanol (EPL) extracts, and polysaccharides (PSCPL) of cultured P. linteus fruiting bodies in lipopolysaccharide (LPS)-induced human monocytic (THP-1) cells, as well as investigating the chemical properties of PSCPL. Results showed that at concentrations <10 mu g/mL, PSCPL with molecular weight ranging from 22 to 1700 kDa was more effective than HPL and EPL in protecting against LPS-induced cell toxicity. At 5 mu g/mL, PSCPL significantly blocked myeloid differentiation factor 88 (MyD88), tumour necrosis factor receptor-associated factor-6 (TRAF-6), vascular cell adhesion molecule-1 (VCAM-1) and nuclear factor-kappa B (NF-kappa B) expression, as well as inhibiting reactive oxygen species (ROS) formation and cytokine (TNF-alpha, IL-1 alpha, IL-1 beta and IL-4) production in LPS-stimulated cells. It also effectively suppressed the activation and phosphorylation of c-Jun N-terminal kinase (JNK) and p38. Taken together, PSCPL shows a stronger immunomodulatory activity than HPL and EPL, and this activity could be mediated through the MyD88-dependent and mitogen-activated protein kinase (MAPK) signaling pathways. (C) 2013 Elsevier Ltd. All rights reserved.
    Appears in Collections:[保健營養系(所) ] 期刊論文

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