English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 18034/20233 (89%)
造訪人次 : 23368934      線上人數 : 497
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/27891


    標題: Neuroprotective effect of agmatine in rats with transient cerebral ischemia using MR imaging and histopathologic evaluation
    作者: Huang, Y. C.
    Tzeng, W. S.
    Wang, C. C.
    Cheng, B. C.
    Chang, Y. K.
    Chen, H. H.
    Lin, P. C.
    Huang, T. Y.
    Chuang, T. J.
    Lin, J. W.
    Chang, C. P.
    貢獻者: 資訊多媒體應用系
    關鍵字: Stroke
    Magnetic Resonance Image
    Agmatine
    Brain Edema
    Pharmacology
    日期: 2013-09
    上傳時間: 2014-05-26 10:47:52 (UTC+8)
    出版者: Elsevier Science Inc
    摘要: Purpose: This study aimed to further investigate the effects of agmatine on brain edema in the rats with middle cerebral artery occlusion (MCAO) injury using magnetic resonance imaging (MRI) monitoring and biochemical and histopathologic evaluation.Materials and methods: Following surgical induction of MCAO for 90 min, agmatine was injected 5 min after beginning of reperfusion and again once daily for the next 3 post-operative days. The events during ischemia and reperfusion were investigated by T2-weighted images (T2WI), serial diffusion-weighted images (DWI), calculated apparent diffusion coefficient (ADC) maps and contrast-enhanced TI-weighted images (CE-TI WI) during 3 h-72 h in a 1.5 T Siemens MAGNETON Avanto Scanner. Lesion volumes were analyzed in a blinded and randomized manner. Triphenyltetrazolium chloride (TTC), Nissl, and Evans Blue stainings were performed at the corresponding sections.Results: Increased lesion volumes derived from T2WI, DWI, ADC, CE-TI WI, and TTC all were noted at 3 h and peaked at 24 h-48 h after MCAO injury. 'ITC-derived infarct volumes were not significantly different from the T2WI, DWI-, and CE-TI WI-derived lesion volumes at the last imaging time (72 h) point except for significantly smaller ADC lesions in the MCAO model (P < 0.05). Volumetric calculation based on TTCderived infarct also correlated significantly stronger to volumetric calculation based on last imaging time point derived on T2WI, DWI or CE-TI WI than ADC (P < 0.05). At the last imaging time point, a significant increase in Evans Blue extravasation and a significant decrease in Nissl-positive cells numbers were noted in the vehicle-treated MCAO injured animals. The lesion volumes derived from T2WI, DWI, CE-T1WI, and Evans blue extravasation as well as the reduced numbers of Nissl-positive cells were all significantly attenuated in the agmatine-treated rats compared with the control ischemia rats (P <0.05).Conclusion: Our results suggest that agmatine has neuroprotective effects against brain edema on a reperfusion model after transient cerebral ischemia. (C) 2013 Elsevier Inc. All rights reserved.
    關聯: Magnetic Resonance Imaging, v.31 n.7, pp.1174-1181
    顯示於類別:[多媒體與遊戲發展系] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML1902檢視/開啟


    在CNU IR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋