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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27890


    標題: Nanocomposite liposomes containing quantum dots and anticancer drugs for bioimaging and therapeutic delivery: a comparison of cationic, PEGylated and deformable liposomes
    作者: Wen, Chih-Jen
    Sung, Calvin T.
    Aljuffali, Ibrahim A.
    Huang, Yu-Jie
    Fang, Jia-You
    貢獻者: 藥學系
    關鍵字: Solid Lipid Nanoparticles
    In-Vivo
    Ultradeformable Liposomes
    Camptothecin Delivery
    Gold Nanoparticles
    Skin Delivery
    Cancer
    Melanoma
    Cells
    Accumulation
    日期: 2013-08
    上傳時間: 2014-05-26 10:47:50 (UTC+8)
    出版者: Iop Publishing Ltd
    摘要: Multifunctional liposomes loaded with quantum dots (QDs) and anticancer drugs were prepared for simultaneous bioimaging and drug delivery. Different formulations, including cationic, PEGylated and deformable liposomes, were compared for their theranostic efficiency. We had evaluated the physicochemical characteristics of these liposomes. The developed liposomes were examined using experimental platforms of cytotoxicity, cell migration, cellular uptake, in vivo melanoma imaging and drug accumulation in tumors. The average size of various nanocomposite liposomes was found to be 92-134 nm. Transmission electron microscopy confirmed the presence of QDs within liposomal bilayers. The incorporation of polyethylene glycol (PEG) and Span 20 into the liposomes greatly increased the fluidity of the bilayers. The liposomes provided sustained release of camptothecin and irinotecan. The cytotoxicity and cell migration assay demonstrated superior activity of cationic liposomes compared with other carriers. Cationic liposomes also showed a significant fluorescence signal in melanoma cells after internalization. The liposomes were intratumorally administered to a melanoma-bearing mouse. Cationic liposomes showed the brightest fluorescence in tumors, followed by classical liposomes. This signal could last for up to 24 h for cationic nanosystems. Intratumoral accumulation of camptothecin from free control was 35 nmol g(-1); it could be increased to 50 nmol g(-1) after loading with cationic liposomes. However, encapsulation of irinotecan into liposomes did not further increase intratumoral drug accumulation. Cationic liposomes were preferable to other liposomes as nanocarriers in both bioimaging and therapeutic approaches.
    關聯: Nanotechnology, v.24 n.32, pp.325101
    Appears in Collections:[藥學系(所)] 期刊論文

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