Molecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulans

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Title:	Molecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulans
Authors:	Yaegashi, Junko Praseuth, Mike B. Tyan, Shiaw-Wei Sanchez, James F. Entwistle, Ruth Chiang, Yi-Ming Oakley, Berl R. Wang, Clay C. C.
Contributors:	生物科技系藥學系
Keywords:	Activated Protein-Kinase Polyketide Synthase Sexual Development Map Kinase Fungus Meroterpenoids Uncovers Product Pathway Stress
Date:	2013-06
Issue Date:	2014-05-26 10:47:45 (UTC+8)
Publisher:	Amer Chemical Soc
Abstract:	Aspernidine A is a prenylated isoindolinone alkaloid isolated from the model fungus Aspergillus nidulans. A genome-wide kinase knockout library of A. nidulans was examined, and it was found that a mitogen-activated protein kinase gene, mpkA, deletion strain produces aspernidine A. Targeted gene deletions were performed in the kinase deletion background to identify the gene cluster for aspernidine A biosynthesis. Intermediates were isolated from mutant strains which provided information about the aspernidine A biosynthesis pathway.
Relation:	Organic Letters, v.15 n.11, pp.2862-2865
Appears in Collections:	[Dept. of Biotechnology (including master's program)] Periodical Articles [Dept. of Pharmacy] Periodical Articles

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