Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27884
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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27884


    Title: Low levels of high-density lipoprotein cholesterol in patients with atherosclerotic stroke: A prospective cohort study
    Authors: Yeh, Poh-Shiow
    Yang, Chun-Ming
    Lin, Sheng-Hsiang
    Wang, Wei-Ming
    Chen, Po-Sheng
    Chao, Ting-Hsing
    Lin, Huey-Juan
    Lin, Kao-Chang
    Chang, Chia-Yu
    Cheng, Tain-Junn
    Li, Yi-Heng
    Keywords: Ischemic Stroke
    High-Density Lipoprotein Cholesterol
    Mortality
    Date: 2013-06
    Issue Date: 2014-05-26 10:47:35 (UTC+8)
    Publisher: Elsevier Ireland Ltd
    Abstract: Objective: The purpose of this study was to evaluate the influence of baseline high-density lipoprotein cholesterol (HDL-C) on initial stroke severity and clinical outcomes in acute ischemic stroke.Methods: From August 2006 through December 2011, patients with acute atherosclerotic ischemic stroke were included. Total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) and HDL-C were checked and National Institutes of Health Stroke Scale (NIHSS) scores were obtained at admission. The primary outcomes were a composite end point of all-cause mortality, recurrent stroke, or occurrence of ischemic heart disease during follow-up.Results: Overall, 3093 subjects (mean age 66.8 years) were included and 675 patients (22%) had low HDL-C (<= 35 mg/dL) at admission. These patients had higher NIHSS scores. After adjusting for all clinical factors in multivariate logistic analysis, low HDL-C at admission (OR, 1.79, 95% CI, 1.40-2.29) was significantly associated with higher stroke severity (NIHSS score > 6). During the follow-up period, 280 patients (9%) developed one of the components of the composite end point, including 76 (11.3%) in patients with low HDL-C and 204 (8.4%) in patients with normal HDL-C at admission (p < 0.001). In multivariate Cox regression analysis, after adjusting for all clinical factors, low HDL-C at admission (HR, 1.41, 95% CI, 1.02-1.95) was a significant independent predictor of the composite end point.Conclusions: Low baseline HDL-C (<= 35 mg/dL) at admission was associated with higher stroke severity and poor clinical outcome during follow-up in patients with atherosclerotic ischemic stroke. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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