Low levels of high-density lipoprotein cholesterol in patients with atherosclerotic stroke: A prospective cohort study

doi:10.1016/j.atherosclerosis.2013.03.015

CNU IR > The Centers > The Center For General Education > Periodical Articles > Item 310902800/27884

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27884

Title:	Low levels of high-density lipoprotein cholesterol in patients with atherosclerotic stroke: A prospective cohort study
Authors:	Yeh, Poh-Shiow Yang, Chun-Ming Lin, Sheng-Hsiang Wang, Wei-Ming Chen, Po-Sheng Chao, Ting-Hsing Lin, Huey-Juan Lin, Kao-Chang Chang, Chia-Yu Cheng, Tain-Junn Li, Yi-Heng
Keywords:	Ischemic Stroke High-Density Lipoprotein Cholesterol Mortality
Date:	2013-06
Issue Date:	2014-05-26 10:47:35 (UTC+8)
Publisher:	Elsevier Ireland Ltd
Abstract:	Objective: The purpose of this study was to evaluate the influence of baseline high-density lipoprotein cholesterol (HDL-C) on initial stroke severity and clinical outcomes in acute ischemic stroke.Methods: From August 2006 through December 2011, patients with acute atherosclerotic ischemic stroke were included. Total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) and HDL-C were checked and National Institutes of Health Stroke Scale (NIHSS) scores were obtained at admission. The primary outcomes were a composite end point of all-cause mortality, recurrent stroke, or occurrence of ischemic heart disease during follow-up.Results: Overall, 3093 subjects (mean age 66.8 years) were included and 675 patients (22%) had low HDL-C (<= 35 mg/dL) at admission. These patients had higher NIHSS scores. After adjusting for all clinical factors in multivariate logistic analysis, low HDL-C at admission (OR, 1.79, 95% CI, 1.40-2.29) was significantly associated with higher stroke severity (NIHSS score > 6). During the follow-up period, 280 patients (9%) developed one of the components of the composite end point, including 76 (11.3%) in patients with low HDL-C and 204 (8.4%) in patients with normal HDL-C at admission (p < 0.001). In multivariate Cox regression analysis, after adjusting for all clinical factors, low HDL-C at admission (HR, 1.41, 95% CI, 1.02-1.95) was a significant independent predictor of the composite end point.Conclusions: Low baseline HDL-C (<= 35 mg/dL) at admission was associated with higher stroke severity and poor clinical outcome during follow-up in patients with atherosclerotic ischemic stroke. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Relation:	Atherosclerosis, v.228 n.2, pp.472-477
Appears in Collections:	[The Center For General Education] Periodical Articles

Files in This Item:

File	Description	Size	Format
310902800_27884.pdf		405Kb	Adobe PDF	801	View/Open
index.html		0Kb	HTML	1677	View/Open

Loading...