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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27862


    標題: In Vitro Efficacies and Resistance Profiles of Rifampin-Based Combination Regimens for Biofilm-Embedded Methicillin-Resistant Staphylococcus aureus
    作者: Tang, Hung-Jen
    Chen, Chi-Chung
    Cheng, Kuo-Chen
    Wu, Kuan-Ying
    Lin, Yi-Chung
    Zhang, Chun-Cheng
    Weng, Tzu-Chieh
    Yu, Wen-Liang
    Chiu, Yu-Hsin
    Toh, Han-Siong
    Chiang, Shyh-Ren
    Su, Bo An
    Ko, Wen-Chien
    Chuang, Yin-Ching
    貢獻者: Chi Mei Med Ctr, Dept Med
    Chi Mei Med Ctr, Dept Med Res
    Natl Cheng Kung Univ, Dept Med, Med Coll & Hosp
    Natl Cheng Kung Univ, Inst Biotechnol, Med Coll & Hosp
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    關鍵字: Field Gel-Electrophoresis
    Antimicrobial Agents
    Fusidic Acid
    Infections
    Tigecycline
    日期: 2013-11
    上傳時間: 2014-05-26 10:46:42 (UTC+8)
    出版者: Amer Soc Microbiology
    摘要: To compare the in vitro antibacterial efficacies and resistance profiles of rifampin-based combinations against methicillin-resistant Staphylococcus aureus (MRSA) in a biofilm model, the antibacterial activities of vancomycin, teicoplanin, daptomycin, minocycline, linezolid, fusidic acid, fosfomycin, and tigecycline alone or in combination with rifampin against biofilm-embedded MRSA were measured. The rifampin-resistant mutation frequencies were evaluated. Of the rifampin-based combinations, rifampin enhances the antibacterial activities of and even synergizes with fusidic acid, tigecycline, and, to a lesser extent, linezolid, fosfomycin, and minocycline against biofilm-embedded MRSA. Such combinations with weaker rifampin resistance induction activities may provide a therapeutic advantage in MRSA biofilm-related infections.
    link: http://dx.doi.org/10.1128/AAC.01236-13
    Appears in Collections:[保健營養系(所) ] 期刊論文

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