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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27858

    標題: Impact of head and neck malignancies on risk factors and survival in systemic lupus erythematosus
    作者: Chang, Shih-Lun
    Hsu, Hsin-Te
    Weng, Shih-Feng
    Lin, Yung-Song
    貢獻者: 醫務管理系
    關鍵字: Head And Neck Cancer
    Nasopharyngeal Carcinoma
    Cancer Survival
    Oropharyngeal Carcinoma
    Oral Cancer
    日期: 2013-10
    上傳時間: 2014-05-26 10:46:32 (UTC+8)
    出版者: Informa Healthcare
    摘要: Conclusions: Systemic lupus erythematosus (SLE) is associated with an increased risk of developing a head and neck malignancy (HNM). A history of SLE did not significantly impact the survival of our study cohort after cancer developed. Objectives: To examine the risk and survival rates of HNM in patients with SLE. Methods: This was a population-based, retrospective cohort study. We compared patients newly diagnosed with SLE between 2001 and 2008 (n = 8751) with age-matched controls (1: 10) (n = 87 510). The incidence of HNMs at the end of 2009 was then determined. Results: We found a 2.16-fold higher risk of HNMs in patients diagnosed with SLE compared with the risk of first malignancy in the age-matched controls (incidence rate ratio, IRR = 2.16, p < 0.05). The site with the highest incidence of HNMs in SLE patients was the oral cavity (5/11, 45.45%), followed by the nasopharynx (4/11, 36.36%). SLE displayed no synergic effect on the survival of SLE patients with an HNM compared with age-matched controls with a new HNM (p = 0.2446).
    關聯: Acta Oto-Laryngologica, v.133 n.10 pp.1088-1095
    Appears in Collections:[醫務管理系(所)] 期刊論文

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