Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27815
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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27815


    Title: Curcumin ameliorates methylglyoxal-induced alterations of cellular morphology and hyperpermeability in human umbilical vein endothelial cells
    Authors: Hu, Te-Yu
    Liu, Cheng-Ling
    Chen, Jen-Yin
    Hu, Miao-Lin
    Contributors: 老人服務事業管理系
    Keywords: Methylglyoxal
    Advanced Glycation End Products
    Curcumin
    Huvecs
    Date: 2013-04
    Issue Date: 2014-05-26 10:44:48 (UTC+8)
    Publisher: Elsevier Science Bv
    Abstract: Endothelial dysfunction such as hyperpermeability is one of the characteristics in an early stage of diabetic complications. Curcumin has been shown to inhibit the formation of advanced glycation end products (AGEs) and to trap methyglyoxal (MGO) in cell-free system and in human umbilical vein endothelial cells (HUVECs). Here, we investigated the effect of curcumin on dysfunctions of HUVECs induced by exogenous MGO (30 mu M), which significantly increased intracellular reactive oxygen species (ROS), endothelial permeability, and cytoskeleton rearrangement. In contrast, MOO decreased gap junctional intercellular communication and the expression of connexin 43 and zonula occludens. Pre-treatment of HUVECs with curcumin (0.25-2.5 mu M) significantly ameliorated MGO-induced endothelial dysfunction, whereas pre-treatment with vitamin E (10 mu M) only slightly ameliorated MGO-induced endothelial dysfunction, suggesting that ROS induced by MGO do not play a major role in endothelial dysfunction. These results suggest that curcumin is a potential protective agent against MGO-induced endothelial dysfunction. (C) 2013 Elsevier Ltd. All rights reserved.
    Relation: Journal of Functional Foods, v.5 n.2 pp.745-754
    Appears in Collections:[Dept. of Senior Service and Health Management] Periodical Articles

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