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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27811


    標題: Competitive Inhibition of Mushroom Tyrosinase by Captopril
    作者: Kuo, T. C.
    Ho, F. M.
    貢獻者: 化妝品應用與管理系
    關鍵字: Captopril
    Tyrosinase
    Kinetic Parameter
    Inhibition Mechanism
    Toxicity
    日期: 2013-10
    上傳時間: 2014-05-26 10:44:38 (UTC+8)
    出版者: Research Journal Biotechnology
    摘要: In this study, the kinetic parameters and inhibition mechanism of anti-tyrosinase activity of captopril were investigated in order to provide the basis for the development of novel effective tyrosinase inhibitor. The kinetic analysis showed that the inhibition of captopril on tyrosinase activity was competitive. The half-maximal inhibitory concentration (IC50) and inhibition constant (K-i) were estimated to be 590 mu g/mL and 294 mu M respectively. Furthermore, in vitro studies revealed that tyrosinase did not show any cytotoxicity or nonselective toxicity. These experimental results indicate that captopril may have the potential to be useful in cosmetics or food processing and therefore, it should be investigated further.
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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