Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27787
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    標題: Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry
    作者: Lin, Liang-Tzung
    Chen, Ting-Ying
    Lin, Song-Chow
    Chung, Chueh-Yao
    Lin, Ta-Chen
    Wang, Guey-Horng
    Anderson, Robert
    Lin, Chun-Ching
    Richardson, Christopher D.
    貢獻者: 化妝品應用與管理系
    關鍵字: Chebulagic Acid
    Punicalagin
    Tannin
    Broad-Spectrum Antivirals
    Viral Entry
    Glycosaminoglycans
    日期: 2013-08
    上傳時間: 2014-05-26 10:43:40 (UTC+8)
    出版者: Biomed Central Ltd
    摘要: Background: We previously identified two hydrolyzable tannins, chebulagic acid (CHLA) and punicalagin (PUG) that blocked herpes simplex virus type 1 (HSV-1) entry and spread. These compounds inhibited viral glycoprotein interactions with cell surface glycosaminoglycans (GAGs). Based on this property, we evaluated their antiviral efficacy against several different viruses known to employ GAGs for host cell entry.Results: Extensive analysis of the tannins' mechanism of action was performed on a panel of viruses during the attachment and entry steps of infection. Virus-specific binding assays and the analysis of viral spread during treatment with these compounds were also conducted. CHLA and PUG were effective in abrogating infection by human cytomegalovirus (HCMV), hepatitis C virus (HCV), dengue virus (DENV), measles virus (MV), and respiratory syncytial virus (RSV), at mu M concentrations and in dose-dependent manners without significant cytotoxicity. Moreover, the natural compounds inhibited viral attachment, penetration, and spread, to different degrees for each virus. Specifically, the tannins blocked all these steps of infection for HCMV, HCV, and MV, but had little effect on the post-fusion spread of DENV and RSV, which could suggest intriguing differences in the roles of GAG-interactions for these viruses.Conclusions: CHLA and PUG may be of value as broad-spectrum antivirals for limiting emerging/recurring viruses known to engage host cell GAGs for entry. Further studies testing the efficacy of these tannins in vivo against certain viruses are justified.
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