Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27778
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    標題: Application of an Efficient Gene Targeting System Linking Secondary Metabolites to their Biosynthetic Genes in Aspergillus terreus
    作者: Guo, Chun-Jun
    Knox, Benjamin P.
    Sanchez, James F.
    Chiang, Yi-Ming
    Bruno, Kenneth S.
    Wang, Clay C. C.
    貢獻者: 藥學系
    關鍵字: Cluster
    Identification
    Products
    日期: 2013-07
    上傳時間: 2014-05-26 10:43:18 (UTC+8)
    出版者: Amer Chemical Soc
    摘要: Nonribosomal peptides (NRPs) are natural products biosynthesized by NRP synthetases. A kusA-, pyrG- mutant strain of Aspergillus terreus NIH 2624 was developed that greatly facilitated the gene targeting efficiency in this organism. Application of this tool allowed us to link four major types of NRP-related secondary metabolites to their responsible genes in A. terreus. In addition, an NRP affecting melanin synthesis was also identified in this species.
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