Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyphylla

doi:10.1186/1472-6882-13-237

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/27777

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標題:	Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyphylla
作者:	Lin, Rong-Jyh Yen, Chuan-Min Chou, Tzung-Han Chiang, Feng-Yu Wang, Guey-Horng Tseng, Ya-Ping Wang, Lin Huang, Ting-Wei Wang, Hui-Chuan Chan, Leong-Perng Ding, Hsiou-Yu Liang, Chia-Hua
貢獻者:	化妝品應用與管理系
關鍵字:	Yakuchinone A Antioxidant Adipogenesis Apoptosis Hymenolepis Nana Anisakis Simplex
日期:	2013-09
上傳時間:	2014-05-26 10:43:15 (UTC+8)
出版者:	Biomed Central Ltd
摘要:	Background: Alpinia oxyphylla is a common remedy in traditional Chinese medicine. Yakuchinone A is a major constituent of A. oxyphylla and exhibits anti-inflammatory, antitumor, antibacterial, and gastric protective activities.Methods: Antioxidant and antitumor characteristics of yakuchinone A in skin cancer cells as well as novel mechanisms for the inhibition of adipocyte differentiation, cestocidal activities against Hymenolepis nana adults, and nematocidal activities against Anisakis simplex larvae are investigated.Results: Yakuchinone A presents the ability of the removal of DPPH. and ABTS(+) free radicals and inhibition of lipid peroxidation. Yakuchinone A suppresses intracellular lipid accumulation during adipocyte differentiation in 3 T3-L1 cells and the expressions of leptin and peroxisome proliferator-activated receptor. (PPAR.). Yakuchinone A induces apoptosis and inhibits cell proliferation in skin cancer cells. The inhibition of cell growth by yakuchinone A is more significant for non-melanoma skin cancer (NMSC) cells than for melanoma (A375 and B16) and noncancerous (HaCaT and BNLCL2) cells. Treatment BCC cells with yakuchinone A shows down-regulation of Bcl-2, up-regulation of Bax, and an increase in cleavage poly (ADP-ribose) polymerase (PARP). This suggests that yakuchinone A induces BCC cells apoptosis through the Bcl-2-mediated signaling pathway. The anthelmintic activities of yakuchinone A for A. simplex are better than for H. nana.Conclusions: In this work, yakuchinone A exhibits antioxidative properties, anti-adipocyte differentiation, antitumor activity, and anthelmintic activities against A. simplex and H. nana.
關聯:	Bmc Complementary And Alternative Medicine, v.13 n.237
显示于类别:	[化妝品應用與管理系(所)] 期刊論文

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