Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27659
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    標題: Comparison of Artificial Neural Network and Logistic Regression Models for Predicting In-Hospital Mortality after Primary Liver Cancer Surgery
    作者: Shi, Hon-Yi
    Lee, King-Teh
    Lee, Hao-Hsien
    Ho, Wen-Hsien
    Sun, Ding-Ping
    Wang, Jhi-Joung
    Chiu, Chong-Chi
    貢獻者: 化妝品應用與管理系
    關鍵字: Hepatocellular-Carcinoma
    Genetic Algorithm
    Transplantation
    Risk
    日期: 2012-04-26
    上傳時間: 2014-03-21 16:16:45 (UTC+8)
    出版者: Public Library Science
    摘要: Background: Since most published articles comparing the performance of artificial neural network (ANN) models and logistic regression (LR) models for predicting hepatocellular carcinoma (HCC) outcomes used only a single dataset, the essential issue of internal validity (reproducibility) of the models has not been addressed. The study purposes to validate the use of ANN model for predicting in-hospital mortality in HCC surgery patients in Taiwan and to compare the predictive accuracy of ANN with that of LR model.Methodology/Principal Findings: Patients who underwent a HCC surgery during the period from 1998 to 2009 were included in the study. This study retrospectively compared 1,000 pairs of LR and ANN models based on initial clinical data for 22,926 HCC surgery patients. For each pair of ANN and LR models, the area under the receiver operating characteristic (AUROC) curves, Hosmer-Lemeshow (H-L) statistics and accuracy rate were calculated and compared using paired T-tests. A global sensitivity analysis was also performed to assess the relative significance of input parameters in the system model and the relative importance of variables. Compared to the LR models, the ANN models had a better accuracy rate in 97.28% of cases, a better H-L statistic in 41.18% of cases, and a better AUROC curve in 84.67% of cases. Surgeon volume was the most influential (sensitive) parameter affecting in-hospital mortality followed by age and lengths of stay.Conclusions/Significance: In comparison with the conventional LR model, the ANN model in the study was more accurate in predicting in-hospital mortality and had higher overall performance indices. Further studies of this model may consider the effect of a more detailed database that includes complications and clinical examination findings as well as more detailed outcome data.
    關聯: Plos One, 7(4), e35781
    显示于类别:[化妝品應用與管理系(所)] 期刊論文

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