Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27648
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    標題: Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans
    作者: Ahuja, Manmeet
    Chiang, Yi-Ming
    Chang, Shu-Lin
    Praseuth, Mike B.
    Entwistle, Ruth
    Sanchez, James F.
    Lo, Hsien-Chun
    Yeh, Hsu-Hua
    Oakley, Berl R.
    Wang, Clay C.C.
    貢獻者: 藥學系
    關鍵字: Gene-Cluster
    Biosynthetic-Pathway
    Acid Synthase
    Identification
    Meroterpenoids
    Product
    Naphthopyrone
    Thioesterase
    Metabolites
    Cyclization
    日期: 2012-05-16
    上傳時間: 2014-03-21 16:16:24 (UTC+8)
    出版者: Amer Chemical Soc
    摘要: Genome sequencing has revealed that fungi have the ability to synthesize many more natural products (NPs) than are currently known, but methods for obtaining suitable expression of NPs have been inadequate. We have developed a successful strategy that bypasses normal regulatory mechanisms. By efficient gene targeting, we have replaced, en masse, the promoters of nonreducing polyketide synthase (NR-PKS) genes, key genes in NP biosynthetic pathways, and other genes necessary for NR-PKS product formation or release. This has allowed us to determine the products of eight NR-PKSs of Aspergillus nidulans, including seven novel compounds, as well as the NR-PKS genes required for the synthesis of the toxins alternariol (8) and cichorine (19).
    關聯: Journal of The American Chemical Society, 134(19), 8212-8221
    顯示於類別:[藥學系(所)] 期刊論文

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