Free Radical Scavenging Activity of 4-(3,4-Dihydroxybenzoyloxymethyl)phenyl-O-beta-D-glucopyranoside from Origanum vulgare and Its Protection against Oxidative Damage

doi:10.1021/jf302329m

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Title:	Free Radical Scavenging Activity of 4-(3,4-Dihydroxybenzoyloxymethyl)phenyl-O-beta-D-glucopyranoside from Origanum vulgare and Its Protection against Oxidative Damage
Authors:	Liang, Chia-Hua Chan, Leong-Perng Ding, Hsiou-Yu So, Edmund Cheung Lin, Rong-Jyh Wang, Hui-Min Chen, Ying-Ging Chou, Tzung-Han
Contributors:	化妝品應用與管理系
Keywords:	4-(3,4-Dihydroxybenzoyloxymethyl)Phenyl-O-Beta-D-Glucopyranoside Antioxidant Cytoprotective Origanum Vulgare Reactive Oxygen Species
Date:	2012-08-08
Issue Date:	2014-03-21 16:14:29 (UTC+8)
Publisher:	Amer Chemical Soc
Abstract:	4-(3,4-Dihydroxybenzoyloxymethyl)phenyl-O-beta-D-glucopyranoside (DBPG), a polyphenolic glycoside, isolated from Origanum vulgare has shown 1,1-diphenyl-2-picrylhydrazyl (DPPH center dot)-scavenging capacity in previous work. This study demonstrated that DBPG exhibits antioxidant activity by a series of DPPH center dot, 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS(center dot+)), and superoxide anion radical (O-2(center dot-)) radical-scavenging assays. The inhibition of lipid peroxidation (LP) by DBPG exceeded that by L-ascorbic acid (AA) in a liposome model system. Adding DBPG to mouse liver and brain tissue inhibited the formation of thiobarbituric acid reactive substances (TBARS) to a greater extent than did trolox. In the oxygen stress test, BNLCL2 and HaCaT cells pretreated with DBPG showed increased activities of glutathione peroxidase (GPx), perhaps as a result of reduction of the production of reactive oxygen species (ROS). These findings proved that DBPG had antioxidant activities and a cytoprotective effect in hepatocytes and keratinocytes, suggesting that DBPG may be a useful food and cosmetic additive.
Relation:	Journal of Agricultural And Food Chemistry, 60(31), 7690-7696
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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