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    標題: Antiproliferative Activity and Apoptosis Induction of Eucalyptus Citriodora Resin and Its Major Bioactive Compound in Melanoma B16F10 Cells
    作者: Duh, Pin-Der
    Chen, Zong-Tsi
    Lee, Shwu-Woan
    Lin, Tsuey-Pin
    Wang, Ya-Ting
    Yen, Wen-Jye
    Kuo, Ling-Feng
    Chu, Heuy-Ling
    貢獻者: 食品科技系
    醫藥化學系
    保健營養系
    關鍵字: B16F10 Melanoma Cell
    Eucalyptus Citriodora Resin
    Oxidative Stress
    Apoptosis
    6-[1-(P-Hydroxy-Phenyl)Ethyl]-7-O-Methyl Aromadendrin
    Antiproliferation
    日期: 2012-08-15
    上傳時間: 2014-03-21 16:14:25 (UTC+8)
    出版者: Amer Chemical Soc
    摘要: Antiproliferative activity and apoptosis induction of ethyl acetate of Eucalyptus citriodora resin (EAEER), and its major bioactive compound in melanoma B16F10 cells were investigated. 6-[1-(p-Hydroxy-phenyl)ethyl]-7-O-methyl aromadendrin (HEMA), a flavanol derivative, was isolated from EAEER and identified on the basis of its mass and NMR spectra. The results from MTT assay showed high antiproliferative effects of EAEER and HEMA on B16F10 cells. Moreover, EAEER- and HEMA-induced cell apoptosis was association with the decrease in the mitochondrial transmembrane potentials (Delta psi(m)), increase in Bax/Bcl-2 ratio, and activation of caspase-3. Cells treated with EAEER and HEMA generated intracellular reactive oxygen species (ROS) and nitric oxide (NO), indicating that ROS and RNS play important roles in the induction of apoptosis in B16F10 cells. Taken together, EAEER and its major bioactive compound, HEMA, inhibited the proliferation of B16F10 cells via apoptosis and may be a potential antimelanoma agent.
    關聯: Journal of Agricultural And Food Chemistry, 60(32), 7866-7872
    顯示於類別:[ 食品科技系 ] 期刊論文
    [醫藥化學系 ] 期刊論文
    [保健營養系(所) ] 期刊論文

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