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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27582

    標題: Association of Serum Cytokines, Human Growth Hormone, Insulin-Like Growth Factor (IGF)-I, IGF-II and IGF-Binding Protein (IGFBP)-3 with Coronary Artery Disease
    作者: Hu, Wei-Syun
    Hwang, Jin-Ming
    Tsai, Ying-Lan
    Kuo, Chia-Hua
    Jong, Gwo-Ping
    Kuo, Wu-Hsien
    Tsai, Fuu-Jen
    Tsai, Chang-Hai
    Chung, Li-Chin
    Huang, Chih-Yang
    cmu, library
    貢獻者: 醫務管理系
    關鍵字: Cytokines
    Insulin-Like Growth Factor-I
    Insulin-Like Growth Factor-Ii
    Insulin-Like Growth Factor Binding Protein-3
    Myocardial Infarction
    Percutaneous Coronary Intervention
    日期: 2012-08-31
    上傳時間: 2014-03-21 16:14:15 (UTC+8)
    出版者: Chinese Physiological Soc
    摘要: The roles that serum cytokines, human growth hormone (h-GH), insulin-like growth factor (IGF)-I, IGF-II and IGF-binding protein (IGFBP)-3 play in coronary artery disease (CAD) are not completely clear. A total of 80 participants comprising 20 patients with stable angina (SA), 20 patients with unstable angina (UA), 20 patients with myocardial infarction (MI) and 20 healthy control subjects were recruited during the period January 2010 to August 2010. Blood samples were drawn from all participants on admission and one week later in MI patients undergoing percutaneous coronary intervention (PCI). We found that MI patients had significantly lower levels of IGF-I, IGF-II and IGFBP-3, and significantly higher levels of h-GH, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and IL-10 than controls. Furthermore, patients with SA or UA had higher levels of TNF-alpha and lower levels of IGF-II than control subjects. Moreover, h-GH, IGF-I, IGF-II, IGFBP-3 and IL-6 levels returned to within normal range in MI patients one week after PCI. Our preliminary findings suggest that TNF-alpha and IGF-II are potential biomarkers of early CAD. Furthermore, h-GH, IGF-I, IGF-II, IGFBP-3 and IL-6 might be predictors of and potential modifiable targets for MI.
    關聯: Chinese Journal of Physiology, 55(4), 267-273
    Appears in Collections:[醫務管理系(所)] 期刊論文

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